林水木，男，博士，1986年2月生，广州医科大学药学院，教授，博士生和硕士生导师，广医高水平大学建设“南山学者”骨干人才。本硕博均就读于华南理工大学，曾在新加坡眼科研究所担任Research Associate。主要研究方向为药物化学、抗感染新药研发和生物标志物的检测，致力于解决微生物耐药性的难题。至今已在Accounts Chem Res, J Med Chem, Eur J Med Chem, Sensor Actuat B-Chem等期刊上发表SCI论文25篇。近五年以第一或通讯作者发表SCI论文14篇，含7篇J Med Chem和2篇Eur J Med Chem。2020年作为第一兼通讯作者应邀在Acc Chem Res上撰写关于黄酮类抗菌肽模拟物的综述论文。其中作为第一发明人的关于补骨脂酚类抗菌药物的专利于2021年成功转让给药企。目前主持的在研项目为广州医科大学高水平大学建设人才启动项目(B195002009030，100万)和国家自然科学基金青年项目(21907019，27万)。

联系邮箱：linshuimu020@163.com

主要论文及著作（代表性）：

1. Li, H. X. ^#; Liu, J. Y. ^#; Liu, C. F.; Li, H. Z.; Luo, J. C.; Fang, S. F.; Chen, Y. Z.; Zhong, R. C.; Liu, S. P. ^*; Lin, S. M.^* Design, Synthesis, and Biological Evaluation of Membrane-Active Bakuchiol Derivatives as Effective Broad-Spectrum Antibacterial Agents. J. Med. Chem. 2021, 64, 5603-5619. (IF=7.446，中科院一区)

2. Liu, J. Y. ^#; Li, H. X. ^#; Li, H. Z.; Fang, S. F.; Shi, J. G.; Chen, Y. Z.; Zhong, R. C.; Liu, S. P. ^*; Lin, S. M.^* Rational Design of Dipicolylamine-Containing Carbazole Amphiphiles Combined with Zn(2+) as Potent Broad-Spectrum Antibacterial Agents with a Membrane-Disruptive Mechanism. J. Med. Chem. 2021, 64, 10429-10444. (IF=7.446，中科院一区)

3. Lin, S. M. ^*; Wade, J. D. ^*; Liu, S. P ^*. De Novo Design of Flavonoid-Based Mimetics of Cationic Antimicrobial Peptides: Discovery, Development, and Applications. Acc. Chem. Res. 2021, 54, 104-119. (IF=22.384，中科院一区)

4. Lin, S. M.; Li H. X.; Tao, Y. W.; et al. In Vitro and in Vivo Evaluation of Membrane-Active Flavone Amphiphiles: Semisynthetic Kaempferol-Derived Antimicrobials against Drug-Resistant Gram-Positive Bacteria. J. Med. Chem. 2020, 63, 5797−5815. (IF=7.446，中科院一区)

5. Lin, S. M.; Liu, J. Y.; Li, H. X. et al. Development of Highly Potent Carbazole Amphiphiles as Membrane-Targeting Antimicrobials for Treating Gram-Positive Bacterial Infections. J. Med. Chem. 2020, 63, 9284-9299. (IF=7.446，中科院一区)

6. Chen, Y. Z.; Li, H. X.; Liu, J. Y.; Zhong, R. C.; Li, H. Z.; Fang, S. F.; Liu, S. P.^*; Lin, S. M.^* Synthesis and biological evaluation of indole-based peptidomimetics as antibacterial agents against Gram-positive bacteria. Eur. J. Med. Chem. 2021, 226, 113813. (IF=6.514, 中科院一区)

7. Lin, S. M.^*,#; Chen, Y. Z.^#; Li, H. X.; et al. Design, synthesis, and evaluation of amphiphilic sofalcone derivatives as potent Gram-positive antibacterial agents, Eur. J. Med. Chem. 2020, 202, 112596. (IF=6.514, ^# equal contribution，中科院一区)

8. Zhong, R. C. ^#; Li, H. Z. ^#; Li, H. X.; Fang, S. F.; Liu, J. Y.; Chen, Y. Z.; Liu, S. P. ^*; Lin, S. M.^* Development of Amphiphilic Coumarin Derivatives as Membrane-Active Antimicrobial Agents with Potent In Vivo Efficacy against Gram-Positive Pathogenic Bacteria. ACS Infect. Dis. 2021, 7, 2864-2875. (IF=5.084, 中科院二区)

9. Kumar, G. R.; Rajesh, M.; Lin, S. M.^*; Liu, S. P.^* Propargylic Alcohols as Coupling Partners in Transition-Metal-Catalyzed Arene C−H Activation. Adv. Synth. Catal. 2020, 362, 5238-5256. (IF=5.837，中科院二区)

10. Lin, S. M. ^#; Zhu, C. J. ^#; Li H. X.; et al. Potent in vitro and in vivo antimicrobial activity of semisynthetic amphiphilic γ-mangostin derivative LS02 against Gram-positive bacteria with destructive effect on bacterial membrane. Biochim. Biophys. Acta Biomembr. 2020, 1862, 183353. (IF=3.747, ^# equal contribution，中科院三区)

11. Lin, S. M.; Sin, W. L. W.; Koh, J. J.; et al. Semisynthesis and Biological Evaluation of Xanthone Amphiphilics as Selective, Highly Potent Antifungal Agents to Combat Fungal Resistance. J. Med. Chem. 2017, 60, 10135-10150. (IF=7.446，中科院一区)

12. Lin, S. M.; Koh, J. J.; Aung, T. T.; et al. Semisynthetic Flavone-Derived Antimicrobials with Therapeutic Potential against Methicillin-Resistant Staphylococcus aureus (MRSA). J. Med. Chem. 2017, 60, 6152-6165. (IF=7.446，中科院一区)

13. Lin, S. M.; Koh, J. J.; Aung, T. T.; et al. Symmetrically Substituted Xanthone Amphiphiles Combat Gram-Positive Bacterial Resistance with Enhanced Membrane Selectivity. J. Med. Chem. 2017, 60, 1362-1378. (IF=7.446，中科院一区)

14. Koh, J. J.^#; Lin, S. M. ^#; Aung, T. T.; et al. Amino Acid Modified Xanthone Derivatives: Novel, Highly Promising Membrane-Active Antimicrobials for Multidrug-Resistant Gram-Positive Bacterial Infections. J. Med. Chem. 2015, 58, 739-752. (IF=7.446, ^# equal contribution，中科院一区)

15. Koh, J. J. ^#; Lin, S. M. ^#; Bai, Y. ^#; Sin, W. W. L.; et al. Antimicrobial activity profiles of amphiphilic xanthone derivatives are a function of their molecular oligomerization. Biochim. Biophys. Acta Biomembr. 2018, 1860, 2281-2298. (IF=3.747, ^# equal contribution，中科院三区)

16. Lin, S. M.; Liu, S. P.; Ye, F. Q.; et al. Sensitive detection of DNA by hyperbranched diketopyrrolopyrrole-based conjugated polyelectrolytes. Sensor. Actuat. B-Chem. 2013, 182, 176-183. (IF=7.46，中科院一区)

17. Lin, S. M.; Liu, S. P.; Zou, H. X.; et al. Synthesis of Diketopyrrolopyrrole-Containing Conjugated Polyelectrolytes for Naked-Eye Detection of DNA. J. Polym. Sci. Pol. Chem. 2011, 49, 3882-3889. (IF=2.702，中科院三区)

主要专利：

（1）补骨脂酚衍生物、其药学上可接受的盐及其制备方法和应用；林水木，刘寿平，栗宏霞；申请号：202011152645.9；申请日期：2020-10-27。（同时提交国际PCT发明专利申请，申请号：PCT/CN2020/125481）。

（2）黄酮类化合物及其制备方法和应用；林水木，刘寿平，栗宏霞；申请号：201911257926.8；申请日期：2019-12-10，公告日：2020-03-24。

（3）咔唑类化合物及其制备方法和应用；刘寿平，林水木，刘家勇；申请号：201911415794.7；申请日期：2019-12-31，公告日：2020-05-19。