【个人简介】
张东阳,博士,广州医科大学南山学者教授。2018年6月博士毕业于中山大学化学学院,2018年10月至2021年9月,于深圳大学医学部从事博士后研究工作,主要研究方向涉及纳米载体药物递送和多模态成像系统的设计与应用、纳米抗氧化剂在急性肾损伤、肿瘤等疾病诊疗的应用等。目前已在Nat. Commun.、Adv. Funct. Mater.、Adv. Sci.、Biomaterials、Chem. Eng. J.、Small以及Theranostics等国际高水平期刊上发表SCI论文33篇,其中第一作者和共同第一作者发表论文15篇(IF>10, 8篇),论文他引540多次,个人h-index为14。主持广州医科大学“高水平大学建设项目”引进高层次人才科研启动项目、博士后基金面上项目等。
【联系方式】
E-mail: zhangdy7@gzhmu.edu.cn
【教育经历】
Ø 2013.08—2018.06 中山大学 化学学院 无机化学 博士
Ø 2009.08—2013.06 四川大学 化学学院 化学基地班 本科
【工作经历】
Ø 2021.11—至今 广州医科大学 药学院 南山学者教授
Ø 2018.10—2021.10 深圳大学医学部 生物医学工程学院 博士后
【科研方向】
Ø 纳米载体药物递送和多模态成像系统的设计与应用
Ø 纳米抗氧化剂在急性肾损伤、肿瘤等活性氧相关疾病诊疗的应用
Ø 纳米材料通过表观遗传调控治疗肿瘤机制研究
【主持的科研项目】
1. 广州医科大学“高水平大学建设项目”引进高层次人才科研启动,2022-01至2026-12,200万,主持
2. 中国博士后基金面上项目,磷化亚铜纳米片用于癌症多模式成像指导的联合治疗(011977),8万,结题,主持
【专利申请】
1. 黄鹏,张东阳,刘恒克,林静;一种用于急性肾损伤的纳米酶诊疗剂及其制备方法与应用;专利号:202011119819.1;2020年10月19日;中国;发明专利。
2. 黄鹏,张东阳,刘恒克,林静;一种用于急性肾损伤的纳米酶药物及其制备方法与应用;专利号:202011328317.X;2020年11月24日;中国;发明专利。
3. 黄鹏,张东阳,刘恒克,林静;一种用于急性肾损伤的纳米酶诊疗剂及其制备方法与应用;专利号:202011328063.1;2020年11月24日;中国;发明专利。
【讲授课程】
本科生课程:《有机化学》
代表性论文(*通讯作者,#共同作者):
1. Dong-Yang Zhang, Yue Zheng, Hang Zhang, Jing-Hua Sun, Cai-Ping Tan*, Liang He, Wei Zhang, Liang-Nian Ji and Zong-Wan Mao*, Delivery of Phosphorescent Anticancer Ir(III) Complexes by Polydopamine Nanoparticles for Targeted Combined Photothermal-Chemotherapy and Thermal/Photoacoustic/Lifetime Imaging. Adv. Sci., 2018, 5, 1800581. (IF: 16.806)
2. Dong-Yang Zhang, Muhammad Rizwan Younis, Hengke Liu, Shan Lei, Yilin Wan, Junle Qu, Jing Lin and Peng Huang*, Multi-enzyme mimetic ultrasmall iridium nanozymes as reactive oxygen/nitrogen species scavengers for acute kidney injury management. Biomaterials, 2021, 271, 120706. (IF: 12.479)
3. Dong-Yang Zhang#, Hengke Liu#, Muhammad Rizwan Younis, Shan Lei, Chen Yang, Jing Lin, Junle Qu and Peng Huang*, Ultrasmall Platinum Nanozymes as Broad-Spectrum Antioxidants for Theranostic Application in Acute Kidney Injury. Chem. Eng. J., 2021, 409, 127371. (IF: 13.273)
4. Dong-Yang Zhang#, Hengke Liu#, Ting He, Muhammad Rizwan Younis, Tianhui Tu, Chen Yang, Jing Zhang, Jing Lin, Junle Qu and Peng Huang*, Biodegradable self-assembled ultrasmall nanodots as reactive oxygen/nitrogen species scavengers for theranostic application in acute kidney injury. Small, 2021, 17, 2005113. (IF: 13.281)
5. Dong-Yang Zhang#, Tianhui Tu#, Muhammad Rizwan Younis#, Kathy S. Zhu, Hengke Liu, Shan Lei, Junle Qu, Jing Lin and Peng Huang* Clinically Translatable Gold Nanozymes with Broad Spectrum Antioxidant and Anti-inflammatory Activity for Alleviating Acute Kidney Injury. Theranostics. 2021, 11, 9904–9917. (IF: 11.556)
6. Dong-Yang Zhang#, Hengke Liu#, Kathy S Zhu, Ting He, Muhammad Rizwan Younis, Chen Yang, Shan Lei, Jiayingzi Wu, Jing Lin, Junle Qu, and Peng Huang*, Prussian Blue-Based Theranostics for Ameliorating Acute Kidney Injury. J. Nanobiotechnol., 2021, 19, 1–14. (IF: 10.435)
7. Dong-Yang Zhang#, Hengke Liu#, Muhammad Rizwan Younis#, Shan Lei, Yunzhi Chen, Peng Huang*, and Jing Lin*, In-Situ TiO2-x Decoration of Titanium Carbide Mxene for Photo/Sono-Responsive Antitumor Theranostics, J. Nanobiotechnol., 2022, 20, 1–14. (IF: 10.435)
8. Dong-Yang Zhang, Yue Zheng, Cai-Ping Tan*, Jing-Hua Sun, Wei Zhang, Liang-Nian Ji, and Zong-Wan Mao*, Graphene Oxide Decorated with Ru(II)-Polyethylene Glycol Complex for Lysosome-Targeted Imaging and Photodynamic/Photothermal Therapy. ACS Appl. Mater. Interfaces, 2017, 9, 6761–6771. (IF: 9.229)
9. Dong-Yang Zhang#, Fanglin Huang#, Yan Ma, Guangzhong Liang, Zhuo Peng, Shixia Guan*, Junqiu Zhai*, Tumor Microenvironment-Responsive Theranostic Nanoplatform for Guided Molecular Dynamic/Photodynamic Synergistic Therapy. ACS Appl. Mater. Interfaces, 2021, 13, 17392–17403. (IF: 9.229)
10. Dong-Yang Zhang#, Hengke Liu#, Chunying Li#, Muhammad Rizwan Younis, Shan Lei, Chen Yang, Zhiming Li, Jing Lin, Junle Qu and Peng Huang*, Ceria Nanozymes with Preferential Renal Uptake for Acute Kidney Injury Alleviation. ACS Appl. Mater. Interfaces, 2020, 12, 56830−56838. (IF: 9.229)
11. Yue Zheng#, Yuyi Ling#, Dong-Yang Zhang#, Hang Zhang, Cai-Ping Tan*, Gang-Gang Yang, Liang-Nian Ji, Hongsheng Wang*, and Zong-Wan Mao*. Regulating Tumor N6‐Methyladenosine Methylation Landscape using Hypoxia‐Modulating OsSx Nanoparticles. Small, 2021, 17, 2005086. (IF: 13.281)