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李莹

 


【个人简介】

李莹,教授,南山学者骨干人才,深圳市海外高层次人才2015年获得华中科技大学博士学位(优秀毕业生),2013-2015国家纳米科学中心联合培养博士;2015-2019香港科技大学唐本忠院士团队博士后,2019-2022深圳大学AIE研究中心副研究员2022年5月加入广州医科大学药学院,为药学院AIE药剂生物学创新研究中心执行负责人中心于7月成立)。研究工作主要致力设计、开发应用于多药耐药(MDR)菌感染和癌症疾病诊疗的新型聚集诱导发光(AIE)材料,并探究其相关治疗机理。目前已在国际权威SCI期刊发表科研论文50篇,其中以一作/通讯作者在Nat. Commun., Sci. Adv., Adv. Mater., Angew. Chem. Int. Ed., Adv. Funct. Mater., Adv. Sci., ACS Nano等期刊发表研究论文24篇(IF >10, 18篇),其中2篇选为封面文章,论文被引用1700余次。多次受邀参加国际、国内会议,曾获得“The Best Paper Award”和“Best Poster Award”奖励;申请6项中国专利(2项已授权)、1项美国专利;主持了国家自然科学基金青年科学基金、面上基金、深圳市基础研究重点项目和广州医科大学“高水平大学建设项目”人才启动项目;担任Front. Chem.期刊(IF = 5.221)客座副主编和编委。

 

【联系方式】

liying5797@126.com

 

【研究方向】

  1. 新型AIE材料的设计与开发病原微生物检测、肿瘤标志物检测试剂盒开发;

  2. AIE光敏剂、AIE纳米药物的合成与应用(肿瘤/病原微生物感染多模态诊疗);AIE纳米药物调控肿瘤微环境、增强免疫治疗;

  3. MDR菌、胞内菌杀菌靶点及机制探究;抗菌/癌增效剂AIE药物的开发及机制探究;

     

    主持基金

  4. 用于细菌介导肿瘤诊疗的近红外荧光体系的构建及应用研究。项目编号:22275040,国家自然科学基金面上项目,2023.01-2026.12    54万    主持

  5. 广州医科大学高水平大学建设项目人才启动项目 项目编号:02-412-2202-2137,

    2022.05-2027.05    200万    主持

  6. 用于胞内耐药致病菌感染诊疗的聚集诱导发光体系的构建与应用研究。 项目编号:22005195,国家自然科学基金青年科学基金,2021.01-2023.12    24万    主持

  7. 2020N392肿瘤靶向分子成像及诊疗一体化荧光探针的应用研究。项目编号:JCYJ20200109110608167,深圳市基础研究(重点项目)2020.11-2023.11  250万 主持                                                                                   

    【专利】

  8. 一种细菌纤维素基光敏抗菌敷料及其制备方法与应用。李莹, 沈紫鹏, 杨光, 王东。专利号: 202210138478.5

  9. 一种聚集诱导发光材料及其制备方法与应用。李莹, 吴逸璠, 王东, 李建高。专利号:202210151118.9

  10. 一种双光子激发诊疗一体化纳米材料及其制备方法与应用唐本忠, 李莹 专利号:202010627192.4

  11. 一种用于监测和杀死多药耐药细菌的双功能聚集诱导发光材料。唐本忠, 李莹, 赵征。专利号:CN201980040725.4

  12. AIE luminogen for montioring and killing of multidrug-resistant bacteria. Ben Zhong Tang, Ying Li, Zheng Zhao. 专利号:TTC.PA.01175  美国专利

  13. 细菌纤维素小直径人工血管的制备方法及应用。蒋兴宇, 李莹, 郑文富专利号:201611248232.4 授权

  14. 一种微流控芯片及使用其的评价伤口敷料的方法蒋兴宇, 李莹, 杨光, 郑文富专利号:ZL 201410400234.5 授权                 

【讲授课程】【实验课程】

微生物药物学                                                                                           

【代表性论文】

  1. Y. Li,# F. Liu,# J. J. Zhang, X. Y. Liu, P. H. Xiao, H. T. Bai, S. Chen, D. Wang, S. H. P. Sung, R. T. K. Kwok, J. Z. Shen, K. Zhu,* B. Z. Tang* Efficient Killing of Multidrug-Resistant Internalized Bacteria by AIEgens in Vivo. Adv. Sci. 2021, 2001750. (IF = 17.521) (封面)

  2. Y. Li,# R.B. Tang,# X.Y. Liu, J.Y. Gong, Z. J. Zhao, Z. H. Sheng, J. J. Zhang, X. Y. Li, G. L. Niu, R. T. K. Kwok, W. F. Zheng,* X.Y. Jiang,* B. Z. Tang* Bright Aggregation-Induced Emission Nanoparticles for Two-Photon Imaging and Localized Compound Therapy of Cancers. ACS Nano 2020, 14, 16840-16853. (IF = 18.027)

  3. Y. Li,# Z. Zhao,# J. J. Zhang, R. T. K. Kwok, S. Xie, R. B. Tang, Y. X. Jia, J. C. Yang, L. Wang, J. W. Y. Lam, W. F. Zheng,* X. Y. Jiang,* B. Z. Tang* A Bifunctional Aggregation-induced Emission Luminogen for Monitoring and Killing of Multidrug-resistant Bacteria.Adv. Funct. Mater. 2018, 201804632. (IF = 19.927)

  4. Y. Li, Y. Tian, W. S. Zheng, Y. Feng, R. Huang, J. X. Shao, R. B. Tang, P. Wang, Y. X. Jia, J. J. Zhang, W. F. Zheng,* G. Yang,* X. Y. Jiang* Composites of Bacterial Cellulose and Small Molecule-Decorated Gold Nanoparticles for Treating Gram-Negative Bacteria-Infected Wounds.Small 2017, 201700130. (IF = 15.153)

  5. Y. Li, K. Jiang, J. Feng, J. Z. Liu, R. Huang, Z. J. Chen, J. C. Yang, Z. H. Dai, Y. Chen, N. X. Wang, W. J. Zhang, W. F. Zheng,* G. Yang,* X. Y. Jiang* Construction of small-diameter vascular graft by shape-memory and self-rolling bacterial cellulose membrane. Adv. Healthc. Mater. 2017, 1601343. (IF = 11.092)

  6. W. P. Zhu,# Y. Li,# S. X. Guo, W. J. Guo, T. K. Peng, H. Li, B. Liu, H. Q. Peng,* B. Z. Tang* Stereoisomeric Engineering of Aggregation-Induced Emission Photosensitizers towards Fungal Killing. Nat. Commun. 2022, 20560. (IF = 17.694) (Nature Press)

  7. J. J. Zhang,# Y. Li,# F. L. Chai,# Q. Z. Li, D. Wang, L. P. Liu,* B. Z. Tang,* X. Y. Jiang* Ultrasensitive Pointof-Care Biochemical Sensor Based on Metal-AIEgen Frameworks. Sci. Adv. 2022, 8, eabo1874.  (IF = 14.957) (Science Press)

  8. R. H. Dong,# Y. Li,# M. Chen, P. H. Xiao, Y. F. Wu, K. Zhou, Z. Zhao,* B. Z. Tang* In situ electrospinning of AIE complexed nanofibrous dressing for wound healing. Small Methods 2022, 2101247. (IF = 15.367)

  9. X.-M. Cai,# Y. T. Lin,# Y. Li,# X. F. Chen, Z. Y Wang, X. Q. Zhao, S. L. Huang,* Z. Zhao,* B. Z. Tang* BioAIEgens Derived from Rosin: How Does Molecular Motion Affect Their Photophysical Processes in Solid State? Nat. Commun. 2021, 12, 1773. (IF = 17.694) (Nature Press)

  10. Z. Hu,# Y. Li,# M. M. Kang, M. M. Islam, M. S. Chen, J. Zhang, Y. Xiao, X. Feng,* C. Redshaw, M. L. Zhang,* Q. Chen, S. Xie* J. W. Y. Lam, B. Z. Tang*Aggregation-induced emission luminogen: A new perspective in photo-degradation of organic pollution. EcoMat 2020, e12024. (封面) (IF = 12.213)

  11. Q. Y. Li, # Y. Li,# T. L. Min,# J. Y. Gong, L. L. Du, K. Li, D. L. Phillips, J. K. Liu, J. W. Y. Lam, H. H. Y. Sung, I. D. Williams, R. T. K. Kwok, J. G. Wang,* B. Z. Tang* Time-dependent Photodynamic Therapy for Multiple Targets: A Highly Efficient AIE-active Photosensitizer for Selective Bacterial Elimination and Cancer Cell Ablation. Angew. Chem. Int. Edit. 2019, 59, 9470-9477. (IF = 16.823)

  12. X. Feng,# Y. Li,# X. W. He, H. X. Liu, Z. Zhao, R. T. K. Kwok, M. R. J. Elsegood, J. W. Y. Lam, B. Z. Tang* A Substitution-dependent Light-up fluorescence probe for selectively detecting Fe3+ ions and its cell imaging application. Adv. Funct. Mater. 2018, 1802833. (IF = 19.927)

  13. Y. F. Wu, J. G. Li, Z. P. Shen, D. L. Wang, R. H. Dong, J. J. Zhang, Y. Z. Pan, Y. Li,* D. Wang,* B. Z. Tang,* Double-pronged Antimicrobial Agents based on a Donor-π-Acceptor Type Aggregation-Induced Emission Luminogen. Angew. Chem. Int. Edit. 2022, 202212386. (IF = 16.823)

  14. J. Y. Gong, P. F. Wei, J. K. Liu, Z. Zhao, W. J. Zhao, C. Ma, J. W. Y. Lam, K. S. Wong, Y. Li,* B. Z. Tang* Polarity‐triggered Anti‐Kasha System for High‐Contrast Cell Imaging and Classification. Aggregate. 2022, AGT2265.

  15. X. H. Wang, M. R. Song, Y. W. Liu, X. Feng,* D. Wang, C. Redshaw, K. Zhu, Y. Li,* B. Z. Tang,* Lipid Droplet-specific Red Aggregation-induced Emission Luminogens: Fast Light-up of Gram-positive pathogens for Identification of Bacteria. ACS Materials Lett. 2022, 4, 1523-1530. (IF = 11.171)

  16. P. H. Xiao, Z. P. Shen, D. L. Wang, Y. Z. Pan, Y. Li,* J. Y. Gong, L. Wang, D. Wang,* B. Z. Tang* Precise Molecular Engineering of Type I Photosensitizers with Near-Infrared Aggregation-Induced Emission for Image-Guided Photodynamic Killing of Multidrug-Resistant Bacteria. Adv. Sci. 2022, 9, 2104079. (IF = 17.521)

  17. H. X. Li, W. Zhu, M. Li, Y. Li,* R. T. K. Kwok, J. W. Y. Lam, L. Wang, D. Wang,* B. Z. Tang* Side Area-Assisted 3D Evaporator with Antibiofouling Function for Ultra-Efficient Solar Steam Generation. Adv. Mater. 2021, 2102258. (IF = 32.086)

  18. X. J. Shi, S. H. P. Sung, J. H. C. Chau, Y. Li,* Z. Y. Liu, R. T. K. Kwok,* J. K. Liu, P. H. Xiao, J. J. Zhang, B. Liu, J. W. Y. Lam, B. Z. Tang* Killing G (+) or G (−) Bacteria? The Important Role of Molecular Charge in AIE-Active Photosensitizers. Small Methods 2020, 2000046. (IF = 15.367)