宫腾-广州医科大学药学院

【个人简介】

宫腾，广州医科大学南山学者特聘教授，博士生导师，广州市高层次人才。2017年博士毕业于华东师范大学，随后留校两年做博士后研究；2020年加入中山大学附属第五医院任副研究员；2021年加入广州医科大学药学院。研究方向：1）临床重大疾病为导向的高性能生物材料的研究，聚焦于抗肿瘤、抗菌和抗炎的新型疗法；2）提出稳态纳米医学概念，在该治疗理念的基础上发展一系列稳态纳米药物用于肿瘤、感染或心血管疾病的高效治疗；3）金属有机框架（MOFs）的设计、合成与功能化，及其在生物医学应用方面的研究。近年来以第一或通讯作者在Angew. Chem. Int. Ed., ACS Nano, Adv. Funct. Mater.等期刊共发表论文15篇，8篇IF>10，文章被引>2000次。申请或授权国家发明专利4项。主持国家自然科学基金（面上、青年）及省市级等项目。课题组有1-2名博士后位置，欢迎相关专业的博士生联系。

【联系邮箱】

tgong@gzhmu.edu.cn

【主持科研项目】

1）国家自然科学基金面上项目，22175046，基于限域电子贴附解离的新型乏氧肿瘤放射动力学疗法，2022/01-2025/12

2）国家自然科学基金青年项目，21805090，放疗X射线诱导激活的新型非氧自由基用于乏氧肿瘤高效治疗，2019/01-2021/12

3）广医大高水平大学人才引进项目，2021/01-2026/01

4）广东省教育厅特色项目，2021KTSCX088，“孔道工程”助力的新一代纳米放疗增敏药物研发，2022/01-2023/12

5）广州市科技计划项目，202201010466，有序多孔纳米级氧化铪放疗增敏药物的设计与开发，2022/04-2024/03

6）中国博士后科学基金，2018M632060，非氧自由基用于乏氧肿瘤放射治疗，2018/06-2020/12

【主要论文及著作（代表性）】

通讯作者：

1) Xiaowen Cai, Junming Li, Ruoqi Zhang, Jie Zhou, Hongmiao Lin, Xiaohua Huang, Chuanshan Xu*, Yanli Li*, and Teng Gong*. Homeostatic nanomedicine: Protein S-nitrosylation dyshomeostasis dominated oncotherapy based on a tumor-microenvironment-activated nanoparticle, Chem. Eng. J., 2024, 500, 157029.

2) Shuangpiao Deng, Kaixin Ou, Chenyu Zhang, Daojing Yuan, Xiaowen Cai, Fengtan Li, Xuetao Wang, Jing Yin^*, Chuanshan Xu^*, Yanli Li^*, and Teng Gong^*. A one-two punch strategy for diabetic wound management based on an antibiotic-hybrid biomineralized iron sulfide nanoparticle, Acta Biomater., 2024, 181, 333-346.

3) Yue Zhao, Cheng-Lan Li, Chao-Qin Chen, Jing Du, ao Lin, Xiaohua Huang, Ulrich Kortz^*, Teng Gong^*, and Peng Yang^*. Last piece of the puzzle: lead-assisted assembly of an arsenopalladate nanostar as an antitumor metallodrug, Inorg. Chem. Front., 2024, 11, 1413.

4) Jianwen Huang, Shuai Wang, You Zhou, Qiuxia Li, Jing Yin, Dailong Zha, Junyang Zhong, Wenmin Zhou, Chengkun Zheng, Yingling Miao, Wenjie Chen, Chuanshan Xu^*, Yanli Li^*, and Teng Gong^*. Nanoformulations Mediated Metastasis Brake in Cancer Therapy via Photodynamic-Enhanced Ferroptosis and Regional Inflammation Management, Chem. Eng. J., 2023, 451, 138585.

5) Yanli Li, Teng Gong^*, Hongbao Gao, Yang Chen, Huiyan Li, Peiran Zhao, Yaqin Jiang, Kun Wang, Yelin Wu, Xiangpeng Zheng^*, and Wenbo Bu^*. ZIF-based Nanoparticles Combine X-Ray-Induced Nitrosative Stress with Autophagy Management for Hypoxic Prostate Cancer Therapy, Angew. Chem. Int. Ed., 2021, 60, 15472-15481.

6) Yanli Li, Peiran Zhao, Teng Gong^*, Han Wang, Xingwu Jiang, Hui Cheng, Yanyan Liu, Yelin Wu^*, and Wenbo Bu^*. Redox Dyshomeostasis Strategy for Hypoxic Tumor Therapy Based on DNAzyme-Loaded Electrophilic ZIFs, Angew. Chem. Int. Ed., 2020, 59, 22537-22543.

第一作者:

7) Geyong Guo^#, Teng Gong^#, Hao Shen^#, Qiaojie Wang, Feng Jiang, Jin Tang, Xingwu Jiang, Jiaxing Wang^*, Xianlong Zhang^*, and Wenbo Bu^*. Self-Amplification Immunomodulatory Strategy for Tissue Regeneration in Diabetes Based on Cytokine-ZIFs System, Adv. Funct. Mater., 2021, 2100795.

8) Teng Gong^#, Yanli Li^#, Bin Lv^#, Han Wang, Weiqiang Ge, Yanyan Liu^*, Wei Yang, Yelin Wu, Xingwu Jiang, Hongbo Gao, Xiangpeng Zheng^*, and Wenbo Bu^*. Full-Process Radiosensitization Based on Nanoscale Metal-Organic Frameworks, ACS Nano, 2020, 14, 3032-3040.

9) Teng Gong, Qi Sui, Peng Li, Xianfu Meng, Li-Jiao Zhou, Jinquan Chen, Jianhua Xu, Lin Wang, and En-Qing Gao^*. Versatile and Switchable Responsive Properties of a Lanthanide-Viologen Metal-Organic Framework, Small, 2019, 15, 1803468.

10) Teng Gong, Peng Li, Qi Sui, Jinquan Chen, Jianhua Xu and En-Qing Gao^*. A Stable Electron-Deficient Metal-Organic Framework for Colorimetric and Luminescence Sensing of Phenols and Anilines, J. Mater. Chem. A, 2018, 6, 9236-9244.

11) Teng Gong, Peng Li, Qi Sui, Li-Jiao Zhou, Ning-Ning Yang, and En-Qing Gao^*. Switchable Ferro-, Ferri-, and Antiferromagnetic States in a Piezo- and Hydrochromic Metal-Organic Framework, Inorg. Chem., 2018, 57, 6791-6794.

12) Teng Gong^#, Xiaobing Lou^#, En-Qing Gao^* and Bingwen Hu^*. Pillared-Layer Metal-Organic Frameworks for Improved Lithium-Ion Storage Performance, ACS Appl. Mater. Interfaces, 2017, 9, 21839-21847.

13) Teng Gong, Xiao Yang, Jia-Jia Fang, Qi Sui, Fu-Gui Xi, and En-Qing Gao^*. Distinct Chromic and Magnetic Properties of Metal−Organic Frameworks with a Redox Ligand, ACS Appl. Mater. Interfaces, 2017, 9, 5503-5512.

14) Teng Gong^#, Xiaobing Lou^#, Jia-Jia Fang, En-Qing Gao^*, and Bingwen Hu^*. A Novel Coordination Polymer Based on Co(II) Hexanuclear Clusters with Azide and Carboxylate Bridges: Structure, Magnetism and Its Application as a Li−Ion Battery Anode, Dalton Trans., 2016, 45,19109-19116.

15) Teng Gong, Xiao Yang, Qi Sui, Yan Qi, Fu-Gui Xi, and En-Qing Gao^*. Magnetic and Photochromic Properties of a Manganese(II) Metal−Zwitterionic Coordination Polymer, Inorg. Chem., 2016, 55, 96-103.