【个人简介】

黄玉刚，教授，2011获中山大学高分子化学与物理博士学位；目前为广州医科大学药学院研究生导师，主要从事生物医用高分子材料在药物靶向递送以及医疗器械领域的应用基础研究。在ACS Macro. Lett, Chem. Mater, Chem. Commun等期刊以第一或通讯作者身份发表SCI论文30余篇，H-index 19；是AM、Angew、Acta Biomater和ACS Macro Lett等期刊审稿人；担任SCI收录期刊Int. J. Polym. Sci (Wiley出版社)学术编辑；目前授权发明专利3项；主持国家自然科学基金青年基金、省教育厅重点专项等纵向项目6项、横向项目1项；作为项目主要成员获得2020年广东省科技进步奖一等奖、2021广东省药理学会科技成果奖二等奖、2024年广东医学科技奖二等奖各1项;指导本科生获2025年“挑战杯”广东省总决赛二等奖1项。

【联系方式】hyug@gzhmu.edu.cn

【研究方向】

1. 小分子、核酸等药物高分子靶向递送载体；2.医疗器械表面功能性涂层材料开发；3. 功能高分子材料

【代表性论文】（2020~Present）

1. S. F. Li, J. Y. Zhong, Y. X. Ma, C. F. Yue, W. X. Lv, G. D. Ye, X. M. Tian, X. Li*, Y. G. Huang*, L. R. Du*. Influences of chain length and conformation of guanidinylated linear synthetic polypeptides on nuclear delivery of siRNA with potential application in transcriptional gene silencing. Int. J. Biol. Macromol. 2025, 308, 142743.

2. X. J. Lu, J. J. Qiu, Y. L. Li, M. Cai, X. H. Yang, S. F. Li, G. D. Ye, W. Yi*, Y. G. Huang*. PEGylation can effectively strike a balance in siRNA delivery performances of guanidinylated linear synthetic polypeptides with potential use for transcriptional gene silencing. ACS Macro Lett. 2024, 13, 1251–1257.

3. Y. L. Li, J. L. Zhong, X. J. Lu, M. Cai, H. Y. Zhu, G. D. Ye, W. Yi*, C. S. Xu*, Y. G. Huang*. Preparation of tumor-targeting pH-Sensitive polymeric nanoprodrugs through the self-assembly of biotinylated polymer–drug conjugates utilizing a simple Diels–Alder chemical strategy. Chem. Mater. 2024, 36, 10142–10153.

4. Y. D. Zhang, Q. Tang, M. Cai, J. T. Cai, S. F. Li, X. M. Deng, L. R. Du, G. D. Ye, C. S. Xu, Y. G. Huang*. A simple and efficient strategy for preparing anticoagulant coatings on biomedical polyurethane surfaces through a fluorinated urethane prepolymer. Prog. Org. Coat. 2024, 191, 108421.

5. Y. D. Zhang, J. Zhao, J. T. Cai, X. J. Ai, P. Q. Zhang, H. W. Hu, C. S. Xu, M. H. He, G. D. Ye, Y. G. Huang*. Synthesis, UV-curing behaviors and general properties of acrylate-urethane resins prepared from castor oil-based polyols. Prog. Org. Coat. 2024, 188, 108204.

6. Y. G. Huang, H. Y. Liao, R. S. Huang, L. J. Huang, G. Xie, H. W. Hu, J. W. Yang*. Bis(trimethylsilyl)amino modified Type II photoinitiators can alleviate oxygen inhibition of near-UV LED photopolymerization due to moisture induced decomposition of initiators. Eur. Polym. J. 2022, 172, 111236.

7. J. Y. Zhong, Y. S. Quan, X. Y. Zhao, S. F. Li, Z. Q. He, G. D. Ye, M. N. Sun, Y. L. Miao, C. P. Ma, H. K. Yang, X. Chen, Y. G. Huang*. Coassembling functionalized glycopolypeptides to prepare pH-responsive self-indicating nanocomplexes to manipulate selfassembly/drug delivery and visualize intracellular drug release. Biomater. Adv. 2022, 134, 112711.

8. X. L. Jiang, J. J. Fu, J. Y. Zhong, X. Li, H. Wang, S. J. Zhong, Y. H. Wei, X. Y. Zhao, X. Chen, Y. Zhou, L. R. Du, G. D. Ye, J. Zhao, Y. G. Huang*. Guanidinylated cyclic synthetic polypeptides can effectively deliver siRNA by mimicking the biofunctions of both cell-penetrating peptides and nuclear localization signal peptides. ACS Macro Lett. 2021, 10, 767–773.

9. X. Y. Chen, J. Y. Zhong, X. L. Jiang, Z. Q. He, Y. S. Quan, S. J. Zhong, G. J. Li*, Y. G. Huang*. Structure and oxidation effects on conformation and thermoresponsiveness of the OEGylated poly(glutamic acid)-bearing side-chain thioether linkers. Langmuir. 2021, 37, 1288–1296.

【科研项目】

1. NSFC青年基金(51403043)、25万。具有生物功能性的多肽基纳米载体系统的构建及二级结构的基础作用研究

2. 广东省教育厅重点专项、15万。构建基于环形聚氨基酸的高分子载体材料以改善聚合物胶束的肿瘤组织渗透性

【发明专利】

1. 一种细胞毒性低、转染效率高的非病毒基因转染载体材料及其制备方法与应用。授权号：ZL 201710113970.6；发明人：黄玉刚、易玲

2. 一类基于阳离子螺旋多肽的非病毒基因转染载体材料。授权号：ZL 20161113 6867.5；发明人：黄玉刚、易玲、叶国东、黄珺珺

3. 具有穿膜活性和细胞核定位功能的抗血清、低细胞毒性的聚氨基酸类基因递送载体。授权号：ZL 202111084127.2，发明人：黄玉刚; 姜欣林