【个人简介】

申翱，博士，广州医科大学南山学者引进人才、药学院副教授、博士研究生导师。

国际心脏研究学会（ISHR）中国分会副秘书长，中国病理生理学会心血管青年委员会委员，中国药理学会表观遗传药理学专业委员会委员，广东省药理学会常务理事，广东省药理学会心血管药理专业委员会常务委员，广东省医学会医学科研实验室建设与管理学分会委员。

武汉大学生命科学学院生物学基地班专业理学学士、武汉大学生命科学学院微生物专业理学博士。

曾为美国加州大学伯克利分校公共卫生学院传染病学系访问学者、武汉大学病毒学国家重点实验室讲师、美国加州大学戴维斯分校医学院药理学系博士后。作为课题负责人或学术骨干先后获多项国家级项目资助，如科技部973计划、国家自然科学基金重点项目、面上项目、青年项目、国家留学基金委联合培养博士奖学金、美国心脏学会AHA Postdoctoral Fellowship等。在Nature Communications、eLife、Science Signaling、JVI等发表SCI论文超过30篇。

【联系邮箱】

shenao@gzhmu.edu.cn

【研究方向】

胸腔疾病的分子机制和药理学研究、新药筛选、疾病快速诊断和靶向治疗。

【代表性论著】

Joseph M. Martinez#, Ao Shen#, Bing Xu, Aleksandra Jovanovic, Josephine de Chabot, Jin Zhang, Yang K. Xiang. Arrestin-dependent nuclear export of phosphodiesterase 4D promotes GPCR-induced nuclear cAMP signaling required for learning and memory. Science Signaling, 2023, 16(778):eade3380.

Huan-Tian Zhang#, Rui Peng#, Sheng Chen#, Ao Shen, Lixin Zhao, Wang Tang, Xiao-He Wang, Zhen-Yan Li, Zhen-Gang Zha*, Mengmeng Yi*, Lingmin Zhang*. Versatile nano-PROTAC-induced epigenetic reader degradation for efficient lung cancer therapy. Advanced Science, 2022, 9(29):e2202039.

Aiping Qin#, Sheng Chen#, Songpei Li#, Qizhen Li, Xiaotao Huang, Luoxing Xia, Yinshan Lin, Ao Shen*, Andy Peng Xiang*, Lingmin Zhang*. Artificial stem cells mediated inflammation-tropic delivery of antiviral drugs for pneumonia treatment. Journal of Nanobiotechnology, 2022, 20(1):335.

Huili Ren, Yingxiang Chen, Zhou Ao, Qi Cheng, Xiaoyan Yang, Hua Tao, Lixin Zhao, Ao Shen, Peiyuan Li*, Qin Fu*. PDE4D binds and interacts with YAP to cooperatively promote HCC progression. Cancer Letters, 2022, 541:215749.

Lu Liang#, Wenyan Xu#, Ao Shen#, Huiyu Cen, Zhijun Chen, Lin Tan, Lingmin Zhang, Yu Zhang, Jijun Fu, Aiping Qin, Xueping Lei, Songpei Li, Yuyan Qin*, Jionghua Huang*, Xiyong Yu*. Promoter methylation-regulated miR-148a-3p inhibits lung adenocarcinoma (LUAD) progression by targeting MAP3K9. Acta Pharmacologica Sinica, 2022, 43(11):2946-2955.

Guanlie Li#, Haiqing He#, Guodong Zheng#, Wenjing Jiang, Shuwen Du, Hua Tao, Tao Xiao, Dazhi Zhou, Shangwei Ding, Xi-Yong Yu, Yu Zhang*, Ao Shen*. Direct detection of pulmonary fibrosis by near-infrared-responsive biomimetic platelets. International Journal of Nanomedicine, 2022, 17: 151-162.

Xiang Tao#, Haiqing He#, Jiangtong Peng#, Rui Xu, Jing Fu, Yuting Hu, Li Li, Xiaoyan Yang, Xiuling Feng, Chao Zhang, Lingmin Zhang, Xi-Yong Yu, Ao Shen*, Kai Huang*, Qin Fu*. Overexpression of PDE4D in mouse liver is sufficient to trigger NAFLD and hypertension in a CD36-TGF-β1 pathway: therapeutic role of roflumilast. Pharmacological Research, 2022, 175:106004.

Chuangjia Huang#, Xiaoling Guan#, Hui Lin#, Lu Liang, Yueheng Wu, Xiaodan Wu, Ao Shen*, Minyan Wei*, Jionghua Huang*. Efficient photoacoustic imaging with biomimetic mesoporous silica-based nanoparticles. Frontiers in Bioengineering and Biotechnology, 2021, 9:762956.

Xin Huang#, Ao Shen#, Rui Peng#, Sheng Chen, Shitao Lin, Shangwei Ding*, Huan Li*, Dazhi Zhou*. A novel biomimetic nanoprobe as photoacoustic contrast agent. Frontiers in Chemistry, 2021, 9:721799.

Jun Chen, Guanlie Li, Haiqing He, Xin Li, Wenjing Niu, Di Cao, Ao Shen*. Sumoylation of the carboxy-terminal of human cytomegalovirus DNA polymerase processivity factor UL44 attenuates viral DNA replication. Frontiers in Microbiology, 2021, 12:652719

Ao Shen, Xi-Yong Yu. “Histone lysine demethylase inhibitor (HDMi) as chemo-sensitizing agent”, in Epigenetic Regulation in Overcoming Chemoresistance, 1th Ed, eds Chunfu Wu, Lihui Wang. Elsevier Press, 2021, 41–55. doi: 10.1016/B978-0-12-823684-0.00007-4

Ao Shen, Xi-Yong Yu. “Targeting histone lysine methyltransferases for drug sensitization”, in Epigenetic Regulation in Overcoming Chemoresistance, 1th Ed, eds Chunfu Wu, Lihui Wang. Elsevier Press, 2021, 57–67. doi: 10.1016/B978-0-12-823684-0.00003-7

Guanlie Li, Ao Shen*, Xi-yong Yu*. Epigenetic regulation in pulmonary heart disease by non-coding RNA. Chinese Pharmacological Bulletin, 2021, 37(3):317.

Ao Shen, Dana Chen, Manpreet Kaur, Peter Bartels, Bing Xu, Qian Shi, Joseph M. Martinez, Kwun-nok Mimi Man, Madeline Nieves-Cintron, Johannes W. Hell, Manuel F. Navedo, Xi-Yong Yu, Yang K. Xiang. Xiang*. β-blockers augment LTCC activity by targeting spatially restricted β2AR signaling in neurons. eLife. 2019, 8: e49464.

Ao Shen, Madeline Nieves-Cintron , Yawen Deng , Qian Shi , Dhrubajyoti Chowdhury , Jinyi Qi , Johannes W. Hell , Manuel F. Navedo, Yang K. Xiang*. Functionally distinct and selectively phosphorylated GPCR subpopulations co-exist in a single cell. Nature Communications. 2018, 9: 1050.

Tommaso Patriarchi#, Ao Shen#, Wei He, Mo Baikoghli, Holland R. Cheng, Yang K. Xiang, Matthew A. Coleman*, Lin Tian*. Nanodelivery of a functional membrane receptor to manipulate cellular behavior. Scientific Reports. 2018, 8(1): 3556.

Celine I. Maeder, Jae-Ick Kim, Xing Liang, Konstantin Kaganovsky, Ao Shen, Qin Li, Zhaoyu Li, Sui Wang, X.Z. Shawn Xu, Jin Billy Li, Yang K. Xiang, Jun B. Ding*, Kang Shen*. The THO complex coordinates transcripts for synapse development and dopamine neuron survival. Cell. 2018, 174(6):1436.

Wei Zou, Ao Shen, Xintong Dong, Madina Tugizova, Yang K. Xiang, Kang Shen*. A multi-protein receptor-ligand complex underlies combinatorial dendrite guidance choices in C. elegans. eLife. 2016, 5: e18345.

Kamila Skieterska, Ao Shen, Dorien Clarisse, Pieter Rondou, Dasiel Oscar Borroto-Escuela, Beatrice Lintermans, Kjell Fuxe, Yang K. Xiang, Kathleen Van Craenenbroeck*. Characterization of the interaction between the dopamine D4 receptor, KLHL12 and β-arrestins. Cellular Signalling. 2016, 28(8): 1001.

Hongyu Zhao, Ao Shen, Yang K. Xiang, David P. Corey*. Three Engineered recombinant antibodies against recombinant tags with high affinity and specificity. PLoS ONE. 2016, 11(3): e0150125.

Ao Shen#, Ji Lei#, Edward Yang#, Yonggang Pei, Chuan-Yuan Chen, Hao Gong, Gengfu Xiao, Fenyong Liu*. Human cytomegalovirus primase UL70 specifically interacts with cellular factor Snapin. Journal of Virology. 2011, 85(22): 11732.

Yanni Chen, Ao Shen, Paul J. Rider, Yi Yu, Kailang Wu, Yongxin Mu, Qian Hao, Yingle Liu, Hao Gong, Ying Zhu, Fenyong Liu*, Jianguo Wu*. A liver-specific miRNA binds to a highly conserved RNA sequence of hepatitis B virus and negatively regulates viral gene expression and replication. The FASEB Journal. 2011, 25(12): 4511.

【发明专利】

1. 余细勇，赵丽鑫，申翱。双吲哚马来酰胺类化合物的新应用，2022-12-6，中国，ZL202110302524.6

2. 余细勇，朱昱光，申翱，张灵敏。靶向DNA去甲基化的方法、融合蛋白及其应用，2022-12-9，中国，ZL202210050631.9

3. 申翱，何海清，杜淑雯，张灵敏。治疗肺动脉高压的吸入剂的仿生肺表面活性物载体和药物，2022-11-8，中国，CN202210957604.X

4. 余细勇，申翱，陶华，赵丽鑫，钟南山。多肽偶联小分子化合物及其抗病毒应用，2022-12-13，中国发明专利，CN202310567902.2

5. 余细勇，赵丽鑫，陶华，申翱，林勇浩。咪唑并[1,2-a]吡嗪类化合物的新应用，2023-7-14，中国发明专利，CN202310867035.4

【科研项目】

1. 国家自然科学基金面上项目，82070406，β1受体通过二聚体-单体转换引发心力衰竭时β受体信号异常的机制研究，2021/01-2024/12，55万，主持。

2. 广东省教育厅特色创新项目，2020KTSCX106，心脏中二聚化β1肾上腺素受体的关键作用及其对心力衰竭的影响，2021/01-2022/12，5万，主持。

3. 广东省自然科学基金面上项目，2020A1515011158，β受体亚群介导的β受体阻滞剂偏好性信号转导研究，2019/10-2022/09，10万，主持。

4. 广州医科大学高水平大学建设人才科研启动项目，B195002009033，2018/10-2023/10，100万，主持。

5. 美国心脏协会(American Heart Association, AHA) WSA Postdoctoral Fellowship，14POST20380053，PKA and GRK phosphorylation define two distinct subpopulations of beta2 adrenoceptor in cardiomyocytes。 2014/07-2016/07，$86000，主持。

6. 国家自然科学基金青年科学基金项目，31100128，人巨细胞病毒DNA引发酶UL70同宿主因子的相互作用研究。2012/01-2014/12，22万，主持。

7. 国家自然科学基金重点项目，81030031，人巨细胞病毒复制必需蛋白与宿主细胞因子相互作用的生物学效应研究。2011/01-2014/12，200万，项目骨干。

8. 国家重点基础研究发展计划(973计划)，2011CB504800，病毒潜伏感染的分子机制。2011/01-2015/12，490万，项目骨干。

【所获荣誉和奖励】

2019            广州市高层次人才（广州市）

2018            南山学者（广州医科大学）

2007            联合培养博士奖学金（国家留学基金委）