王玉青，女，博士，广州医科大学药学院药物化学教研室副教授。2013获中山大学药学专业学士学位，2018获中山大学药物化学博士学位。2018年7月入职广州医科大学药学院，工作至今。目前已在国内外重要刊物上发表SCI论文十余篇，申请专利多项。主持国家自然科学基金1项、广东省教育厅项目基金1项、广州市科技厅项目1项、广州医科大学大学生实验室开放项目1项、参与多项国家级和省级项目。参与本科教学课程《有机化学》、《药物化学》、《波谱解析》、《新药研究与开发应用》。

联系方式：gzhmu-wyq@foxmail.com

研究方向：

1、以核酸和蛋白质为靶标的抗肿瘤药物的设计、合成、活性评价和作用机制研究。

2、天然产物、小分子化合物、脂质体、纳米材料等的靶标与活性研究。

代表性研究成果：

[1].Yu-Qing Wang, Zhou-Li Huang, Shuo-Bin Chen, Chen-Xi Wang, Chan. Shan, Qing-Kun Yin, Tian-Miao Ou, Ding Li, Lian-Quan Gu, Jia-Heng Tan* and Zhi-Shu Huang*. Design, Synthesis, and Evaluation of New Selective NM23-H2 Binders as c-MYC Transcription Inhibitors via Disruption of the NM23-H2/G-quadruplex Interaction. Journal of Medicinal Chemistry, 2017, 60(16), 6924−6941.

[2].Yu-Qing Wang#, Ming-Hao Hu#, Rui-Jun Guo, Shuo-Bin Chen*, Zhi-Shu Huang and Jia-Heng Tan*. Tuning the Selectivity of a Commercial Cyanine Nucleic Acid Dye for Preferential Sensing of Hybrid Telomeric G-Quadruplex DNA. Sensors & Actuators: B. Chemical. 2018, 266, 187-194.

[3].Ming-Hao Hu#, Yu-Qing Wang#, Ze-Yi Yu, Lu-Ni Hu, Tian-Miao Ou, Shuo-Bin Chen*, Zhi-Shu Huang and Jia-Heng Tan*. Discovery of a New Four-Leaf Clover-Like Ligand as a Potent c-MYC Transcription Inhibitor Specifically Targeting the Promoter G-Quadruplex. Journal of Medicinal Chemistry, 2018, 61(6), 2247−2459.

[4].Tong Che, Yu-Qing Wang, Zhou-Li Huang, Jia-Heng Tan, Zhi-Shu Huang and Shuo-Bin Chen*. Natural Alkaloids and Heterocycles as G-Quadruplex Ligands and Potential Anticancer Agents. Molecules, 2018, 23, 493.

[5].Chan Shan#, Jin-Wu Yan#, Yu-Qing Wang, Tong Che, Zhou-Li Huang, Ai-Chun Chen, Pei-Fen Yao, Jia-Heng Tan, Ding Li, Tian-Miao Ou*, Lian-Quan Gu and Zhi-Shu Huang*. Design, Synthesis and Evaluation of Isaindigotone Derivatives to Downregulate c-myc Transcription via Disrupting the Interaction of NM23-H2 with G-Quadruplex. Journal of Medicinal Chemistry, 2017, 60 (4), 1292–1308.

[6].Ming-Hao Hu, Shuo-Bin Chen, Yu-QingWang, You-Mei Zeng, Tian-Miao Ou, Ding Li, Lian-Quan Gu Zhi-Shu Huang and Jia-Heng Tan*. Accurate High-throughput Identification of Parallel G-quadruplex Topology by a New Tetraaryl-substituted Imidazole. Biosensors and Bioelectronics, 2016, 83, 77-84.

[7].Qi-Kun Yin#, Chen-Xi Wang, Yu-Qing Wang, Shuo-Bin Chen*, and Zhi-Shu Huang* etc. Discovery of Isaindigotone Derivatives as Novel Bloom’s Syndrome Protein (BLM) Helicase Inhibitors That Disrupt the BLM/DNA Interactions and Regulate the Homologous Recombination Repair. J. Med. Chem., 2019, 62 (6), 3147–3162

[8].Tong Che, Shuo-Bin Chen, Jia-Li Tu, Bo Wang, Yu-Qing Wang, Yan Zhang, Jing Wang, Zeng-Qing Wang, Ze-Peng Zhang, Tian-Miao Ou, Yong Zhao, Jia-Heng Tan* and Zhi-Shu Huang*. Discovery of Novel Schizocommunin Derivatives as Telomeric G-Quadruplex Ligands That Trigger Telomere Dysfunction and the Deoxyribonucleic Acid (DNA) Damage Response J. Med. Chem, .2018, 61(8), 3436-3453

发明专利：

[1].黄志纾，谭嘉恒，王玉青，一种7位氟取代Isaindigotone衍生物及其制备方法在制备抗癌药物中的应用，申请号2016105959362

[2].黄志纾，谭嘉恒，王玉青，王晨曦，一种喹唑啉酮与α，β-不饱和酮轭合衍生物及其制备方法和应用，申请号2017106589526