研 究 方 向

- 过渡金属催化反应机理的理论研究

- 量子化学计算

- 新型材料设计的理论研究

- 计算机辅助药物设计

工 作 经 历

2023.7 – 至今     广州医科大学 药学院 | 讲师

2022.1 – 2023.7   广州医科大学 药学院 | 博士项目研究人员

合作导师：黄思铭 / 易伟 教授

2018.11 – 2021.10 广州医科大学 药学院 | 博士后

合作导师：易伟 教授

2015.9 – 2018.9   中山大学 化学学院 | 特聘副研究员

合作导师：赵存元 教授

教 育 经 历

2009.9 – 2015.7   中山大学 / [美]埃默里大学，联合培养理学博

士（硕博连读），物理化学专业，导师：赵存元 教授 / Dr. Djamaladdin

G. Musaev（联合培养）

2005.9 – 2009.7   中山大学，化学与化学工程学院，材料化学专业，理学学士

主 持 项 目

- 中国博士后科学基金面上资助（依托广州医科大学）：过渡金属催化C-H键环丙烷化的实验与理论研究（2019M662854），已结题。

- 国家自然科学基金青年项目（依托中山大学）：非贵金属催化含氮杂环化合物的交叉偶联反应的理论研究（21603279），2017.01 – 2019.12，已结题。

研 究 成 果

已发表SCI论文38篇，其中以第一作者或共同第一作者身份发表论文13篇，以通讯作者发表论文2篇。（截至2023/10/16）

代表性论文如下（按时间倒序）：

[1] Yi Wang,^† Ping Qi,^† Hui Gao,* Zhi Zhou, Wei Yi,* Huiying Xu.* Mechanistic Insights to Define the Directional Role of Hydrogen-Bonding Network between Aryl Oximes and Propargyl Alcohols in Rh(III) Catalysis. Mol. Catal. 2023, 550, 113448.

[2] Ping Qi,^†,* Qingqiong Zhou,^† Guiyun Chen, Zihao Lin, Jinli Zhao, Huiying Xu,* Hui Gao, Donghao Liu, Xinwu Mao.* Simultaneous qualitative and quantitative determination of 104 fat-soluble synthetic dyes in foods using disperse solid-phase extraction and UHPLC-Q-Orbitrap HRMS analysis. Food Chem. 2023, 427, 136665.

[3] Zhen-Yu Wang,^† Huiying Xu,^† Xu Zhang, Xing Wang, Hui Xu,* Hui Gao,* Hui-Xiong Dai.* Dual ligands relay-promoted transformation of unstrained ketones to polyfluoroarenes and nitriles. Sci. China Chem. 2023, 66, 2037.

[4] Yidi Li,^† Huiying Xu,^† Zhi Zhou,* Lin Huang, Zhenhao Tang, Wei Yi,* Xiaowei Wu.* An unusual four-step cascade reaction for accessing furo[3,4-c]pyridine-1,4-diones via rhodium catalysis. Org. Chem. Front. 2023, 10, 4658.

[5] Yidi Li,^† Huiying Xu,^† Lin Huang,^† Zhi Zhou,* Zhenhao Tang, Haifang Meng, Wei Zhang, Wei Yi,* Xiaowei Wu.* Rhodium-catalyzed regioselective C–H activation/Lossen rearrangement/annulation for the green synthesis of trisubstituted 2-pyridones. Org. Chem. Front. 2023, 10, 3000.

[6] Wei Yi,^†* Weijie Chen,^† Huiying Xu,^† Kaifeng Chen, Xiuhua Zhong, Zhi Zhou.* Os(II)-catalyzed γ-C(sp³)–H amidation and meta-C(sp²)–H alkylation by fine-tuning the characteristics of in-situ-generated C–Os σ bonds. Cell Rep. Phys. Sci. 2023, 4, 101423.

[7] Haifang Meng,^† Huiying Xu,^† Zhi Zhou,^† Zhenhao Tang, Yidi Li, Yu Zhou,* Wei Yi,* Xiaowei Wu.* Recyclable rhodium-catalyzed C-H activation/[4+2] annulation with unconventional regioselectivity at ambient temperature: experimental development and mechanistic insight. Green Chem. 2022, 24, 7012.

[8] Yinhui Wei,^† Huiying Xu,^† Fangyuan Chen, Hui Gao, Yugang Huang, Wei Yi,* Zhi Zhou.* Specific Assembly of Dihydrobenzofuran Frameworks via Rh(III)-Catalysed C-H Coupling of N-Phenoxyacetamides with 2-Alkenylphenols. New J. Chem. 2022, 46, 5705.

[9] Huiying Xu,^† Weijie Chen,^† Mengyao Bian,^† Hongtao Xu, Hui Gao, Ting Wang, Zhi Zhou,* Wei Yi.* Gem-Difluorocyclopropenes as Versatile β-Monofluorinated Three-sp² Carbon Sources for Cp*Rh(III)-Catalyzed [4+3] Annulation: Experimental Development and Mechanistic Insight. ACS Catal. 2021, 11, 14694.

[10] Liexin Wu,^† Huiying Xu,^† Hui Gao, Liping Li, Weijie Chen, Zhi Zhou,* Wei Yi.* Chiral Allylic Amine Synthesis Enabled by the Enantioselective Cp^XRh(III)-Catalyzed Carboaminations of 1,3-Dienes. ACS Catal. 2021, 11, 2279.

[11] Huiying Xu,^† Mengyao Bian,^† Zhi Zhou, Hui Gao,*Wei Yi.* Mechanistic insights into the dual directing groups-mediated C-H functionalization/annulation via hydroxyl group-assisted M^III-M^V-M^III pathway. ACS Omega. 2021, 6, 17642.

[12] Xu Zhang,^† Zhi Zhou,^† Huiying Xu,^† Xuefeng Xu, Xiyong Yu,* Wei Yi.* Cobalt-Catalyzed Allylation of Amides with Styrenes Using DMSO as Both the Solvent and the alpha-Methylene Source. Org. Lett. 2019, 21, 7248.

[13] Huiying Xu, Kei Muto, Junichiro Yamaguchi, Cunyuan Zhao, Kenichiro Itami,* Djamaladdin G. Musaev.* Key Mechanistic Features of Ni-catalyzed C­H/C­O Biaryl Coupling of Azoles and Naphthalen-2-yl Pivalates. J. Am. Chem. Soc. 2014, 136, 14834.