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伏园园


伏园园,女,现为广州医科大学药学院讲师。2020年毕业于中山大学,获理学博士学位;2020年7月到2022年8月在中山大学药学院从事博士后研究。主要研究领域为细胞自噬和药物筛选。以第一作者(含共同)在Autophagy,Redox Biology,Cancers,《中国药理学通报》等国内外学术刊物发表论文数篇,参与申请国家发明专利3项,其中2项已授权。主持国家自然科学基金青年项目一项,广州市基础与应用基础研究专题一项。


联系方式863068184@qq.com

研究方向:药物毒理学、基于自噬相关靶标的药物筛选与活性评价

代表性论文

1. F. Xia#, Y. Fu#, H. Xie#, Y. Chen, D. Fang, W. Zhang, P. Liu, M. Li*, Suppression of ATG4B by copper inhibits autophagy and involves in Mallory body formation. Redox Biology, 52 (2022) 102284.

2. Y. Luo#, Y. Fu#, Z. Huang*, M. Li*, Transition metals and metal complexes in autophagy and diseases. Journal of Cellular Physiology, 236 (2021) 7144-7158.

3. Y. Fu#, Q Gu#, L. Luo#, J. Xu, Y. Luo, F. Xia, F. Han, L. Hong, X.M. Yin, Z. Huang*, M. Li*, New anti-cancer strategy to suppress colorectal cancer growth through inhibition of ATG4B and lysosome function. Cancers, 12 (2020) 6.

4. Y. Fu#, Z. Huang#, L. Hong, J Lu, D. Feng, X.M. Yin, M. Li*, Targeting ATG4 in Cancer Therapy, Cancers (Basel), 11 (2019) 64.

5. Y. Fu#, L. Hong#, J. Xu#, G. Zhong#, Q. Gu, Q. Gu, Y. Guan, X. Zheng, Q. Dai, X. Luo, C. Liu, Z. Huang, X.M. Yin, P. Liu*, M. Li*, Discovery of a small molecule targeting autophagy via ATG4B inhibition and cell death of colorectal cancer cells in vitro and in vivo, Autophagy, 15 (2019) 295-311.

6. M. Li*, Y. Fu, Z. Yang, X.M. Yin*, Measurement of the Activity of the Atg4 Cysteine Proteases, Methods Enzymol, 587 (2017) 207-225.

7. J. Chu#, Y. Fu#, J. Xu#, X. Zheng, Q. Gu, X. Luo, Q. Dai, S. Zhang, P. Liu, L. Hong*, M. Li*, ATG4B inhibitor FMK-9a induces autophagy independent on its enzyme inhibition, Arch Biochem Biophys, 644 (2018) 29-36.

8. Y. Guan, Y. Fu, Y. Liu, S. Wang, M. Zhao, Z. Jin, F. Jiang, L. Hong, M. Huang, M. Li*, G. Zhong*, Quantitative bioanalytical LC-MS/MS assay for S130 in rat plasma-application to a pharmacokinetic study, Bioanalysis, 11 (2019) 1469-1481.