个人简介：

邵攀霖，理学博士，教授，硕士研究生/博士研究生导师。2006年于四川师范大学取得学士学位（导师：赵可清教授），2011年于中国科学院化学研究所取得博士学位（导师：叶松研究员），2012年~2014年于新加坡国立大学从事博士后研究工作（导师：赵宇教授）。长期致力于生物活性分子及药物的不对称合成研究，发展了一系列新颖、独特且高效的不对称催化体系，并将其应用于新药研发以及重大手性药物产业化的关键技术研究。在国内外著名高校与研究机构主持和参与了多个科研项目，研究成果在Chem. Soc. Rev.，Nat. Comput. Sci.，J. Am. Chem. Soc.，Angew. Chem., Int. Ed.，Adv. Sci.，Aggregate等学术期刊发表50余篇；授权发明专利13项。作为负责人和主要参与人，利用关键的平台性技术，开展了数十项大品种原料药的合成工艺开发，包括以多肽药物为导向的系列氨基酸的合成，以及以手性药物为导向的系列小分子原料药的合成。

研究方向：药物化学、体外诊断

主要着眼于手性药物和生物功能材料的开发，具体包括两个研究方向：（1）不对称催化体系的开发并将其应用于手性药物的绿色合成；（2）新型有机小分子荧光“探针”的开发并将其应用于体外诊断。

代表性论文：

(1) Jiaxin Li^#, Jiahu Tang^#, Hancheng Song^#, Ziyi Xu, Shiyu Chen, Ying Liu, Jingkai Yang, Xiaoyang Wen, Zhenzhou Lu, Jiahui Lv, Hongjun Xiao, Jialu Long, Xiaolan Mo,* Jingyuan Song*, Bo Zhang*, Pan-Lin Shao*, Triple Asymmetric Transfer Hydrogenation of 2-Arylidene-1,3-indandiones, Adv. Sci., 2025, DOI: 10.1002/advs.202517370.

(2) Li Cheng^#, Pan-Lin Shao^#*, Jiahui Lv, Hongjun Xiao, Yanping Sun, Jingkai Yang, Ziyi Xu, Mingkun Lv, Guanghui Wang, Shaokang Zhao, Jiaxin Li, Ziqi Jin, Xuan Tan, Guichuan Xing*, Bo Zhang*, Chemistry-informed deep learning model for predicting stereoselectivity and absolute configuration in asymmetric hydrogenation, Nat. Comput. Sci., 2025, DOI: 10.1038/s43588-025-00920-8.

(3) Xu Yan^#, Wei Feng^#, Jiong Xu Ng, Jiaxin Li, Ying Liu, Bo Zhang*, Pan-Lin Shao*, Yu Zhao*, Recent advances in catalytic enantioselective synthesis of vicinal amino alcohols, Chem. Soc. Rev., 2025, 54, 7966−8018.

(4) Ziyi Xu^#, Mingkun Lv^#, Jingkai Yang^#, Tingting Li^#, Jiahui Lv, Jiaxin Li, Hongjun Xiao, Yicheng Yang, Siyu Zhou, Xuan Tan, Li Cheng, Heng Guo, Lei Xi*, Pan-Lin Shao*, Bo Zhang*, An Efficient Heat and Peroxynitrite Generating Nanoplatform for Multimodal Imaging-guided Precision Tumor Phototherapy, Aggregate, 2025, e70040.

(5) Jiahui Lv^#, Tong Li^#, Ying Liu^#, Bing Li, Peng Jia, Chuwei Ma, Hongjun Xiao, Guanghui Wang, Li Cheng, Jingkai Yang, Ziyi Xu, Xuan Tan, Ziqi Jin, Jia-xin Li, Runting Li, Sinan Sun, Eunice Huang, Pan-Lin Shao*, Bo Zhang*, Tunable surface potential nanomaterials for enhanced environmental nucleic acid extraction and surveillance, Water Res., 2025, 287, 124428.

(6) Yi-Ming Luo^#, Jing-Yuan Song^#, Zhong-Jin Yang, Ping Sun, Pan-Lin Shao*, Wen-Hui Hu*, Research advances on the NLRP3 inflammasome and its inhibitors in central nervous system diseases, Acta Pharmaceutica Sinica, 2025, 60, 3396−3407.

(7) Jingkai Yang^#, Ziyi Xu^#, Le Yu, Bingyun Wang, Ruibin Hu, Jiahu Tang, Jiahui Lv, Hongjun Xiao, Xuan Tan, Guanghui Wang, Jia-Xin Li, Ying Liu*, Pan-Lin Shao*, Bo Zhang*, Novel Organic Fluorophores with Large Stokes Shift for the Visualization of Rapid Protein and Nucleic Acid Assays, Angew. Chem., Int. Ed., 2024, 63, e202318800.

(8) Jiahu Tang ^#, Ruibin Hu^#, Yiyi Liu, Jingchao Liu, Guanghui Wang, Jiahui Lv, Li Cheng, Tingzhen He, Ying Liu*, Pan-Lin Shao*, Bo Zhang*, Deciphering ACE2-RBD Binding Affinity through Peptide Scanning: A Molecular Dynamics Simulation Approach, Comput. Biol. Med., 2024, 173, 108325.

(9) Zijuan Yan^#, Pan-Lin Shao^#,*, Qing Qiang^#, Feipeng Liu*, Xuchao Wang, Yongjie Li, Zi-Qiang Rong*, Transition metal-catalyzed conversion of aldehydes to ketones via direct C-H bond functionalization, Chinese Chem. Lett., 2022, 33, 1207−1226.

(10) Jiang Wang, Xin Lin, Pan-Lin Shao*, Jingyuan Song, Jialin Wen, Xumu Zhang*, Double Asymmetric Hydrogenation of α-iminoketones: Facile Synthesis of Enantiopure Vicinal Amino Alcohols, ACS Catal., 2021, 11, 12729−12735.

(11) Kun-Quan Chen,^# He Sheng,^# Qiang Liu, Pan-Lin Shao*, Xiang-Yu Chen*, N-Heterocyclic Carbene-Catalyzed Radical Reactions, Sci. China Chem., 2021, 64, 7−16.

(12) Jiang Wang, Pan-Lin Shao*, Xin Lin, Baode Ma, Jialin Wen, Xumu Zhang*, Facile Synthesis of Enantiopure Sugar Alcohols: Asymmetric Hydrogenation and Dynamic Kinetic Resolution Combined, Angew. Chem., Int. Ed., 2020, 59, 18166−18171.

(13) Jia-Yu Liao,^# Pan-Lin Shao^#, Yu Zhao*, Catalytic Divergent Synthesis of 3H or 1H Pyrroles by [3+2] Cyclization of Allenoates with Activated Isocyanides, J. Am. Chem. Soc., 2015, 137, 628−631.

(14) Pan-Lin Shao, Jia-Yu Liao, Yee Ann Ho, Yu Zhao*, Highly Diastereo- and Enantio-selective Ag-Catalyzed Double [3+2] Cyclization of a-Imino Esters with Isocyanoacetate, Angew. Chem., Int. Ed., 2014, 53, 5435−5439.

(15) Panlin Shao, Li-Tao Shen, Song Ye*, Asymmetric Synthesis of Terminal 1,2-Diols from Acyl Chlorides, Chin. J. Chem., 2012, 30, 2688−2692.

(16) Pan-Lin Shao, Xiang-Yu Chen, Song Ye*, Formal [3+2] Cycloaddition of Ketenes and Oxaziridines Catalyzed by Chiral Lewis Bases: Enantioselective Synthesis of Oxazolin-4-ones, Angew. Chem., Int. Ed., 2010, 49, 8412−8416.

授权专利：

（1）邵攀霖，马保德，王江，丁小兵，张绪穆，合成氢硫酸氯吡格雷及其中间体的新方法，专利号：ZL201910044148.8

（2）邵攀霖，王志鹏，胡平，贺耘，一种杂原子取代的吡咯烷衍生物的不对称合成方法，专利号：ZL201710201866.2

（3）张博，邵攀霖，徐子屹，吕明坤，杨景凯，吕嘉晖，李佳欣，一种近红外二区荧光分子及其制备方法与应用，专利号：ZL202411836914.1

（4）马保德，邵攀霖，吴超，王江，张绪穆，一种羟基酰胺的制备方法，专利号：ZL201910900851.4

（5）马保德，邵攀霖，吴超，王江，张绪穆，ɑ-羟基酸制备方法，专利号：ZL201910044633.5

（6）马保德，邵攀霖，吴超，王江，张绪穆，一种羟基内酰胺的制备方法，专利号：ZL201910901614.X

（7）王志鹏，邵攀霖，贺耘，一种氢氧化钠催化的多取代吡咯合成新方法，专利号：ZL201810735987.X

（8）王志鹏，向四川，邵攀霖，贺耘，一种具有螺环结构的吡咯啉衍生物的不对称合成方法，专利号：ZL201810735998.8

（9）高爽，丁小兵，邵攀霖，一种串联还原胺化合成手性内酰胺的方法，专利号：ZL201910715880.3

（10）谭雪锋，晏邵佰，邵攀霖，张绪穆，钌-双膦催化剂催化的简单酮的不对称还原胺化制备手性伯胺，专利号：ZL201910092496.2

（11）朱绪成，邹毅，邵攀霖，贺耘，制备4-[4-({[4-氯-3-(三氟甲基)苯基]氨基甲酰}氨基)-3-氟苯氧基]-N-甲基吡啶-2-甲酰胺及其一水合物的方法，专利号：ZL201510035485.2

（12）张博，杨景凯，徐子屹，邵攀霖，刘莹，胡瑞彬，肖宏军，一种有机荧光小分子材料、合成方法和应用，专利号：ZL202210368981.X

（13）周兴华，王志鹏，彭小娇，郑绍军，邵攀霖，贺耘，三嗪衍生物的不对称合成方法，专利号：ZL201510154682.6