胡文辉，博士，广东省“珠江学者”特聘教授(2018年-2023年)，药物化学专业博士生导师，学科带头人。现任广州医科大学药学院学术委员会主任，广州蛇毒与生物毒素研究所所长，呼吸病国家重点实验室研究员。

2016.11--至今：特聘教授，药学院学术委员会主任，呼吸病国家重点实验室研究员，广州医科大学。

2006.11--2016.10：研究员，博士生导师，新药开发室主任，呼吸病国家重点实验室研究员，中国科学院广州生物医药与健康研究院。

2002.12--2006.10：博士后，药物研究中心，美国西北大学医学院。

1999.9--2002.7：博士，药物研究所，中国医学科学院和中国协和医科大学。

胡文辉课题组针对未满足临床需求的重大疾病，开展创新药物的研究，建立了国内具有特色和优势的新药研发团队。截至目前，胡教授已申请了30多项国际和国家发明专利，发表了50多篇国际学术论文，兼任药学学报的编委、广东省药学会药物化学专业委员会副主委，药物毒理学会副主委。

在历时20多年的新药研究中，胡教授团队已确立多个全新结构的候选药物。其中，基于神经炎症的抗阿尔茨海默病新药AD16（哌达甲酮），已获得国家食品药品监督管理局（NMPA）颁发的1.1类药物临床试验批件，并完成了I期临床试验，化合物专利涵盖了全球多个国家。

近期代表性学术论文：

1. Xiangyu Yang, Geng Lin, Yitong Chen, Xueping Lei, Yitao Ou, Yuyun Yan, Ruiwen Wu, Jie Yang, Yiming Luo, Lixin Zhao, Xiuxiu Zhang, Zhongjin Yang, Aiping Qin, Ping Sun,* Xi-Yong Yu,* and Wenhui Hu*. Chlorquinaldol Alleviates Lung Fibrosis in Mice by Inhibiting Fibroblast Activation through Targeting Methionine Synthase Reductase. ACS Cent SciACS Central Science. 2024 Aug 28;10(9):1789-1802.

2. Hao Chen, Hu Yue, Yuyun Yan, Nannan Wu, Dan Wu, Ping Sun, Wenhui Hu*, Zhongjin Yang^*. Design, synthesis and biological evaluation of tanshinone IIA derivatives as NLRP3 inflammasome inhibitors. Bioorganic Medicinal Chemical Letters. 2024, 15, 104: 129725.

3. Yitao Ou, Zhongjin Yang, Yinghua Zhou, Hu Yue, Lei Hua, Zhuorong Liu, Geng Lin, Haowei Cai, Yanhong Chen, Wenhui Hu*, Ping Sun^*. Antagonizing interleukin-5 receptor ameliorates dextran sulfate sodium-induced experimental colitis in mice through reducing NLRP3 inflammasome activation. European Journal of Pharmacology. 2024, 15; 965:176331.

4. Haowei Cai, Zhuorong Liu, Ping Sun, Yinghua Zhou, Yuyun Yan, Yiming Luo, Xiuxiu Zhang, Ruiwen Wu, Xiangting Liang, Dan Wu, Wenhui Hu*, Zhongjin Yang^*. Discovery of a dual-acting inhibitor of interleukin-1β and STATs for the treatment of inflammatory bowel disease. RSC Med Chem. 2023 Nov 9;15(1):193-206.

5. Yinghua Zhou^#, Zhongjin Yang^#, Yitao Ou, Haowei Cai, Zhuorong Liu, Geng Lin, Shuli Liang, Lei Hua, Yuyun Yan, Xiuxiu Zhang, Ruiwen Wu, Aiping Qin, Wenhui Hu^*, Ping Sun^*. Discovery of a selective NLRP3-targeting compound with therapeutic activity in MSU-induced peritonitis and DSS-induced acute intestinal inflammation. Cellular and Molecular Life Sciences. 2023, 80(8):230.

6. Xiuhui Chen, Yanhong Chen, Yitao Ou, Wenjie Min， Shuli Liang, Lei Hua, Yinghua Zhou , Cheng Zhan , Peifeng Chen, Zhongjin Yang* , Wenhui Hu* , Ping Sun*，Bortezomib inhibits NLRP3 inflammasome activation and NF-κB pathway to reduce psoriatic inflammation. Biochemical Pharmacology. 2022, (206) 115326 – 115339.

7. Xinyi Wu, Ping Sun, Xiuhui Chen, Lei Hua, Haowei Cai, Zhuorong Liu, Cheng Zhang, Shuli Liang, Yanhong Chen, Dan Wu, Yitao Ou, Wenhui Hu*, and Zhongjin Yang*. Discovery of a novel oral proteasome inhibitor to block NLRP3 inflammasome activation with anti-inflammation activity. Journal of Medicinal Chemistry. 2022 Sep 22, 65(18):11985-12001.  

8. Yanhong Chen#, Xiuhui Chen#, Shuli Liang, Yitao Ou, Geng Lin, Lei Hua, Xinyi Wu, Yinghua Zhou, Zhuorong Liu, Haowei Cai, Zhongjin Yang, Wenhui Hu*, and Ping Sun*. Chlorquinaldol inhibits the activation of nucleotide-binding oligomerization domain-like receptor family pyrin domain-containing protein 3 inflammasome and ameliorates imiquimod-induced psoriasis-like dermatitis in mice. Chemico-Biological Interactions, 2022, 365:110122.

9. Shuli Liang, Zhongjin Yang, Lei Hua, Yanhong Chen, Yinghua Zhou, Yitao Ou, Xiuhui Chen, Hu Yue, Xiangyu Yang, Xinyi Wu, Wenhui Hu*, and Ping Sun*. Ciclopirox inhibits NLRP3 inflammasome activation via protecting mitochondria and ameliorates imiquimod-induced psoriatic inflammation in mice. European Journal of Pharmacology, 2022, 930:175156.

10. Zhihua Huang, Zhengwei Luo, Andrea Ovcjak, Jiangfan Wan, Naihong Chen, Wenhui Hu, HongShuo Sun, ZhongPing Feng. AD-16 Protects Against Hypoxic-Ischemic Brain Injury by Inhibiting Neuroinflammation. Neuroscience Bulletin. 2022, 38: 857–870.

11. Ying Hao, Yitao Ou, Cheng Zhang, Hao Chen, Hu Yue, Zhongjin Yang, Xiaofen Zhong, Wenhui Hu*, and Ping Sun*. Seratrodast, a thromboxane A2 receptor antagonist, inhibits neuronal ferroptosis by promoting GPX4 expression and suppressing JNK phosphorylation. Brain Research. 2022, 148073.

12. Lei Hua, Shuli Liang, Yinghua Zhou, Xinyi Wu, Haowei Cai, Zhuorong Liu, Yitao Ou, Yanhong Chen, Xiuhui Chen, Yuyun Yan, Dan Wu, Ping Sun, Wenhui Hu*, and Zhongjin Yang*. Artemisinin-derived artemisitene blocks ROS-mediated NLRP3 inflammasome and alleviates ulcerative colitis. International Immunopharmacology. 2022, 113, 109431- 109441.

13. Hu Yue, Zhongjin Yang, Yitao Ou, Shuli Liang, Wenmin Deng, Hao Chen, Cheng Zhang, Lei Hua, Wenhui Hu*, Ping Sun*. Tanshinones inhibit NLRP3 inflammasome activation by alleviating mitochondrial damage to protect against septic and gouty inflammation. International Immunopharmacology. 2021, 97, 107819.

14. Cheng Zhang, Hu Yue, Ping Sun, Lei Hua, Shuli Liang, Yitao Ou, Dan Wu, Xinyi Wu, Hao Chen, Ying Hao, Wenhui Hu*, Zhongjin Yang*. Discovery of chalcone analogues as novel NLRP3 inflammasome inhibitors with potent anti-inflammation activities. European Journal of Medicinal Chemistry. 2021, 219, 113417.

15. Hao Chen, Xiuhui Chen, Ping Sun, Dan Wu, Hu Yue, Jintao Pan, Xinxuan Li, Cheng Zhang, Xinyi Wu, Lei Hua, Wenhui Hu*, Zhongjin Yang*. Discovery of dronedarone and its analogues as NLRP3 inflammasome inhibitors with potent anti-inflammation activity. Bioorganic Medicinal Chemistry letter. 2021, 6, 128160.

16. Ping Sun, Hu Yue, Wenming Deng, Yitao Ou, Guangjin Pan, Xiaofen Zhong*, Wenhui Hu*. Compound AD16 reduces amyloid plaque deposition and modifies microglia in a transgenic mouse model of Alzheimer's disease. ACS Pharmacology & Translational Science. 2021, 3, 6, 1100-1110,

17. Jianghong Dong, Mengjie Xiao, Qinge Ma, Guicheng Zhang, Weijie Zhao, Mengjie Kong, Yue Zhang, Luyun Qia, Wenhui Hu*. Design and synthesis of pinane oxime derivatives as novel anti-influenza agents. Bioorganic Chemistry. 2020, 102, 104106-104106.

18. Yitao Ou, Ping Sun, NanNan Wu, Hao Chen, Wenhui Hu*, Zhongjin Yang*. Synthesis and biological evaluation of parthenolide derivatives as potential inhibitors of the NLRP3 inflammasome. Bioorganic Medicinal Chemistry letter. 2020, 30 (17), 127399.

19. Ping Sun, Wei Zhou, Hu Yue, Cheng Zhang, Yitao Ou, Zhongjin Yang^*, Wenhui Hu^*. Compound AD110 Acts as Therapeutic Management for Alzheimer’s Disease and Stroke in Mouse and Rat Models.  ACS Chemical Neuroscience, 2020, 11 (6), 929-938.

20. Wenmin Deng , Zhongjin Yang, Hu Yue, Yitao Ou, Wenhui Hu^*, Ping Sun^*. Disulfiram suppresses NLRP3 inflammasome activation to treat peritoneal and gouty inflammation. Free Radical Biology and Medicine, 2020, 152, 8-17.