【个人简介】

侯宁，博士，药理学教授，博士生导师，广东省优秀青年教师培养对象，广州市高层次人才-青年后备人才，广东省“千百十计划”校级培养对象，广州医科大学南山学者后备人才，广州医科大学高水平大学学术骨干培育对象。中国心血管药理专业委员会委员，中国药理学会教学与科普专业委员会委员，广东省药理学会心血管专业委员会副主任委员，广东省药理学会药理教育专业委员会委员，广东省药理学会炎症免疫专业委员会委员、广东省药理学会代谢药理学专业委员会委员。近年来主持国家级科研项目3项，省市级科研项目10余项，获得经费资助100余万。授权国家专利5项，申请专利4项（排名第一）。在Diabetes、Circulation-Heart Failure、Cardiovascular Research、Archives of Toxicology等杂志发表SCI论文30余篇，Frontiers in Pharmacology杂志特约编辑，Molecules 杂志客座编辑、Engineering、International Journal of Biological Science等多个知名国际期刊专任审稿人。

【联系邮箱】houning-2003@163.com

【研究方向类别】

1、学术学位：药理学，心血管药理学

2、专业学位：临床药学（临床药理学）

【具体研究方向】  

主要研究方向为：（1）心血管发病机制与药物治疗；（2）糖尿病心血管并发症发病机制与防治；（3）新型降糖药物作用评价及分子机制研究。

【主要科研项目】

1. 国家自然科学基金面上项目，82473920，《O-GlcNAc糖基化修饰介导的Yap活化抑制HSP70表达在糖尿病心肌损伤中的作用及机制研究》，2025.01-2028.12，经费48万元，在研，主持。

2. 国家自然科学基金面上项目，81773720，《转录共激活因子Yap/Taz活化导致糖尿病心肌损伤的分子机制研究》，2018/01-2021/12, 经费54万，结题，主持。

3. 广东省自然科学基金面上项目，2023A1515010412 ，PGAM5-β-catenin正反馈环路诱导线粒体动力学失衡导致糖尿病心肌病的机制研究，2023/1/1-2025/12/31，经费10万，在研，主持。

5. 广东省自然科学基金面上项目，2019A1515011848，《细胞内HO-1途径代谢产物胆红素在心肌肥厚中的作用》，2019/10/1-2022/09/30，经费10万，在研，主持。

【主要论文及著作（代表性）】

(1) Li C, Cai D, Yuan W, Cai R, Qiu X, Qin Y, Feng Y, Zhu Q, Liu Y, Chen Y, Yuan X, Jiang W, Hou N. The canonical Wnt/β-catenin signaling pathway upregulates carbonic anhydrase 2 via transcription factor 7-like 2 to promote cardiomyopathy in type 2 diabetic mice. Life Sci. 2025 Feb 25;368:123506.通讯作者

(2) Xu Y, Zheng Z, Jiang X, Wang X, Xu Q, Lu X, Huang Y, Qin Y, Hou N, Liu Y. Inhibition of Bif-1 confers cardio-protection in myocardial infarction. Am J Physiol Cell Physiol. 2025 Mar 1;328(3):C1076-C1089. 共同通讯作者

(3) Xun Yuan, Li Pan, Chi Zhang, Qiulian Zhu, Zexin Huang, Yuan Qin, Guiping Zhang, Zhimei Feng, Caixian Yang and Ning Hou. Empagliflozin improves pressure-overload-induced cardiac hypertrophy by inhibiting the canonical Wnt/β-catenin signaling pathway. Front. Pharmacol. 2024, Nov,24,15:1499542. 通讯作者

(4) Liu Q, Ma L, Chen F, Zhang S, Huang Z, Zheng X, Chen Z, Ye J, Hou N, Yi W, Zhou Z Raloxifene-driven benzothiophene derivatives: Discovery, structural refinement, and biological evaluation as potent PPARγ modulators based on drug repurposing. Eur J Med Chem. 2024 Apr 5; 269: 116325.共同通讯作者

(5) Chen Z, Lai X, Li J, Yuan X, Li Y, Zhang X, Kang Z, Ouyang Z, Zeng J, Hou N, Liu X. BRG1 Deficiency Promotes Cardiomyocyte Inflammation and Apoptosis by Activating the cGAS-STING Signaling in Diabetic Cardiomyopathy. Inflammation. 2025 Feb;48(1):299-315.共同通讯作者

(6) Yue Zeng, Yilang Li , Wenyue Jiang, Ning Hou. Molecular mechanisms of metabolic dysregulation in diabetic cardiomyopathy. Front Cardiovasc Med. 2024 Mar 25:11:1375400. 通讯作者

(7) Yilang Li, Jiaxuan Cai, Yinan Liu , Conglin Li, Xiaoqing Chen, Wing-Leung Wong , Wenyue Jiang, Yuan Qin, Guiping Zhang, Ning Hou, Wenchang Yuan. CcpA-Knockout Staphylococcus aureus Induces Abnormal Metabolic Phenotype via the Activation of Hepatic STAT5/PDK4 Signaling in Diabetic Mice. Pathogens, Pathogens 2023, 12,1300. 共同通讯作者

(8) Xiaoqing Chen, Yilang Li, Xun Yuan, Wenchang Yuan Conglin Li, Yue Zeng，Yuling Lian, Xiaoxia Qiu, Yuan Qin, Guiping Zhang, Xia-Wen Liu, Chengfeng Luo, Jiandong Luo, Ning Hou. Methazolamide attenuates the development of diabetic cardiomyopathy by promoting β-catenin degradation in type 1 diabetic mice. Diabetes. 2022 Apr 1;71(4):795-811. 通讯作者

(9) Ma L, Tang J, Cai G, Chen F, Liu Q, Zhou Z, Zhang S, Liu X, Hou N, Yi W. Structure-based screening and biological validation of the anti-thrombotic drug-dicoumarol as a novel and potent PPARγ-modulating ligand. Bioorg Chem. 2022 Dec;129:106191. 共同通讯作者

(10) Fangyuan Chen, Lei Ma, Guihui Cai, Junyuan Tang, Yi Wang, Qingmei Liu, Xiawen Liu, Ning Hou, Zhi Zhou, Wei Yi, Identification of a novel PPARγ modulator with good anti-diabetic therapeutic index via structure-based screening, optimization and biological validation. Biomedicine & Pharmacotherapy, 2022,154:113653. 共同通讯作者

(11) Yun Liu, Ruixiang Hu, Huanjia Shen, Qinxin Mo, Xinqiuyue Wang, Guiping Zhang, Sujuan Li, Guanfeng Liang, Ning Hou, Jiandong Luo Endophilin A2-mediated alleviation of endoplasmic reticulum stress-induced cardiac injury involves the suppression of ERO1α/IP3R signaling pathway. Int J Biol Sci, 2021 Aug 26;17(13):3672-3688. 通讯作者

(12) Lei Ma , Yuling Lian , Junyuan Tang 1 Fangyuan Chen , Hui Gao , Zhi Zhou , Ning Hou, Wei Yi . Identification of the anti-fungal drug fenticonazole nitrate as a novel PPARγ-modulating ligand with good therapeutic index: Structure-based screening and biological validation. Pharmacol Res. 2021 Nov;173:105860. 共同通讯作者

(13) Ning Hou, Li-Rong Li, Yong-Ying Shi, Wen-chang Yuan, Gan-Jian Zhao, Xia-Wen Liu, Shao-Ai Cai, Yin Huang, HaoXin Zhan, WeiBiao Pan, Cheng-Feng Luo. Azilsartan ameliorates ventricular hypertrophy in rats suffering from pressure overload-induced cardiac hypertrophy by activating the Keap1–Nrf2 signalling pathway.2021, J Pharm Pharmacol. 2021 Dec 7;73(12):1715-1725.

(14) Ning Hou, Yin Huang, Shao-Ai Cai, Wen-Chang Yuan, Li-Rong Li, Xia-Wen Liu, Gan-Jian Zhao, Xiao-Xia Qiu, Ai-Qun Li, Chuan-Fang Cheng, Shi-Ming Liu, Xiao-Hui Chen, Dao-Feng Cai, Jing-Xuan Xie, Min-Sheng Chen, Cheng-Feng Luo. Puerarin Ameliorated Pressure Overload-induced Cardiac Hypertrophy in Ovariectomized Rats Through Activation of the PPARα/PGC-1 pathway. Acta Pharmacologica Sinica, 2021 Jan;42(1):55-67.  

(15) Xiaoping Liu, XunYuan, GuanfengLiang, Shuyun Zhang, Guiping Zhang, Yuan Qin, Qiulian Zhu, Qing Xiao, Ning Hou, Jian-dong Luo. BRG1 protects the heart from acute myocardial infarction by reducing oxidative damage through the activation of the NRF2/HO1 signaling pathway. Free Radical Biology and Medicine. 2020, Nov,160(20):820-836. 通讯作者

(16) Hongqi Chen, Wenliang Chen, Yinlian Yao, Naobei Ye, Ning Hou, Jiandong Luo. Upregulation of CFTR Protects against Palmitate-induced Endothelial Dysfunction by Enhancing Autophagic Flux. Oxidative Medicine and Cellular Longevity. 2020 Oct 17; 2020: 8345246. 通讯作者

(17) Xiaoqing Chen^#, Wenchang Yuan^#, Yilang Li , Jiandong Luo, Ning Hou. Role of Hippo-YAP1/TAZ pathway and its crosstalk in cardiac biology. International journal of biological sciences. Int J Biol Sci 2020 Jul 6;16(13):2454-2463. 通讯作者

(18) Yilang Li, Yunpei Mai, Xiaoxia Qiu, Xiaoqing Chen, Conglin Li, Wenchang Yuan, Ning Hou. Effect of Long-Term Treatment of Carvacrol on Glucose Metabolism in Streptozotocin-induced Diabetic Mice. BMC-Complement Med Ther, 2020, 20(142). 通讯作者

(19) Xiaoqing Chen, Yilang Li , Jiandong Luo , Ning Hou. Molecular mechanism of Hippo–YAP1/TAZ pathway in heart development, disease, and regeneration. Front. Physiol, 2020, 11:389. 通讯作者

(20) Yun Liu, Jie Wei, Kai-Ting M, Cong-Lin Li, Yun-Pei Mai, Xiao-Xia Qiu, Han Wei, Ning Hou, Jian-Dong Luo. Carvacrol protects against diabetes-induced hypercontractility in the aorta through activation of the PI3K/Akt pathway. Biomedicine & Pharmacotherapy. 2020 May;125:109825. 通讯作者

(21) 侯宁; 罗健东; 袁文常; 邱晓霞; 李逸朗; 罗承锋; 蔡少艾. iCRT14化合物在制备治疗I型糖尿病的药物中的应用, 发明专利，授权号：ZL201811487353.3

(22) 刘轶楠;侯宁;郑海婷;郭靖;袁文常;刘芸;蔡桂惠；一种便于操作的尿液取样装置，实用新型专利，授权号：ZL 2022 2 3606328.7。

(23) 侯宁;易伟;周志;蔡道凤;刘青妹;袁勋;马磊;袁文常;蔡桂惠：iCRT14 衍生物及其制备方法和应用，发明专利， 授权号：ZL 2024 1 0501684.7