
【个人简介】
赵林平,医学博士,南山学者“骨干人才”,研究员,硕士研究生导师,广州市卫健委“优秀人才”。2022年7月至今,任职于广州医科大学附属第五医院前沿医学交叉研究中心;近五年以第一作者或通讯作者在ACS Nano,Nano Letters,Advanced Science,Biomaterials,Journal of Controlled Release,Chinese Chemical Letters,Aggregate等国际知名期刊发表SCI论文22篇;主持国家自然科学基金-青年基金项目,广东省自然科学基金-面上项目,广东省普通高校特色创新类项目,广州市科技计划基础与应用基础研究项目,广州医科大学高水平大学建设人才引进项目等,参与项目包括国家重点研发计划-青年科学家项目,国家自然科学基金-青年科学基金项目等;学术任职:广东省药学会医药科研与应用专家委员会委员;《Chinese Chemical Letters》、《Nano TransMed》、《Exploration》青年编委。
【联系邮箱】zlp2022@gzhmu.edu.cn
【研究方向类别】
1、学术学位:
肿瘤学(临床医学)
2、专业学位:
临床药学(医院药学)
【具体研究方向】
药物组装体;药物递送与靶向治疗
【项目主持】
1.国家自然科学基金-青年项目,2024.01.01-2026.12.31,在研,主持。
2.广东省自然科学基金-面上项目,2023.01.01-2025.12.31,在研,主持。
3.广东省自然科学基金-面上项目,2025.01.01-2027.12.31,在研,主持。
4.广东省高校特色创新类项目,2024.10.01-2026.10.31,在研,主持。
5.广州市科技计划项目-基础与应用基础研究项目,2024.04.01-2026.03.31,在研,主持。
6.广州市科技计划项目-博士青年“启航”项目,2024.04.01-2026.03.31,在研,主持。
7.广州医科大学高水平大学人才引进项目,2022.07-2027.07,在研,主持。
【已发表文章】
1. Zhou H Y†, Luo X P†, Huang C Y†, Liu Y X, Li Q Y, Chen G M, Zheng R R, Li S Y*, Zhao L P*. A dual PROTAC nanocarrier amplifies DNA damage and STING activation for cancer immunotherapy. J. Control. Release 2025, 388, 114290.
2. Zhao L P†*, Li J Q†, Chen G M†, Huang C Y, Zhou H Y, Zheng R R, Xu Y Q, Jiang X Y, Chen X H*, Li S Y*, Cuproptosis amplifier of copper-telaglenastat coordinate to trigger cell ferroptosis for synergistic breast cancer suppression. Chin. Chem. Lett. 2025, 110959.
3. Zhang S Y, Zhou H Y, Liu Y X, Chen G M, Li Q Y, Xu Y Q, Zheng R R, Li S Y*, Chen X*, Zhao L P*. A stimuli-responsive immunostimulant to activate chemo-immunotherapeutic effects by inducing DNA damage and STING activation. J. Colloid Interf. Sci. 2025, 688, 664-676
4. Zhao L P†, Zheng R R†, Rao X N†, Huang C Y, Zhou H Y, Yu X Y, Jiang X Y, Li S Y*. Chemotherapy-enabled colorectal cancer immunotherapy of self-delivery nano-PROTACs by inhibiting tumor glycolysis and avoiding adaptive immune resistance. Adv. Sci. 2024, 11, e2309204.
5. Zheng R R†, Huang C Y†, Zhou H Y, Zhao L X, Li Q Y, Chen G M, Zhao L P*, Li S Y*. Multi-synergistic chemotherapeutic drug assemblies to activate colorectal cancer immunotherapy by modulating the multilevel immunosuppressive characteristics. Aggregate 2024, 5, e610.
6. Zhao L P†, Rao X N†, Huang C Y, Zheng R R, Kong R J, Chen Z X, Yu X Y*, Cheng H*, Li S Y*. Epigenetic reprogramming of carrier free photodynamic modulator to activate tumor immunotherapy by EZH2 inhibition. Biomaterials 2023, 293, 121952.
7. Zhao L P†, Rao X N†, Zheng R R, Huang C Y, Kong R J, Yu X Y, Cheng H, Li S Y. Targeting glutamine metabolism with photodynamic immunotherapy for metastatic tumor eradication. J. Control. Release 2023, 357, 460-471.
8. Zhao L P†, Rao X N†, Zheng R R, Huang C Y, Kong R J, Cheng H, Li B, Li S Y. Carrier-Free Nano-PROTACs to Amplify Photodynamic Therapy Induced DNA Damage through BRD4 Degradation. Nano Lett. 2023, 23, 6193-6201.
9. Zhao L P†, Huang C Y†, Zheng R R, Rao X N, Kong R J, Guan R T, Chen Z X, Yu X Y, Cheng H*, Li S Y*. Photodynamic amplified immune checkpoint-blockade therapy of self-delivery bioregulator via epigenetic reprogramming. Chem. Eng. J. 2023, 453, 139729.
10. Zhao L P†, Zheng R R†, Kong R J, Huang C Y, Rao X N, Yang N, Chen A L, Yu X Y*, Cheng H*, Li S Y*. Self-delivery ternary bioregulators for photodynamic amplified immunotherapy by tumor microenvironment reprogramming. ACS Nano 2022, 16, 1182-1197.
11. Zhao L P†, Chen S Y†, Zheng R R†, Kong R J, Rao X N, Chen A L, Cheng H*, Zhang D W*, Li S Y*, Yu X Y*. Self-delivery nanomedicine for glutamine-starvation enhanced photodynamic tumor therapy. Adv. Healthc. Mater. 2022, 11, e2102038.
12. Zhao L P†, Zheng R R†, Liu L S, Chen X Y, Guan R T, Yang N, Chen A L, Yu X Y*, Cheng H*, Li S Y*. Self-delivery oxidative stress amplifier for chemotherapy sensitized immunotherapy. Biomaterials 2021, 275, 120970.
13. Zhao L P†, Chen S Y†, Zheng R R, Rao X N, Kong R J, Huang C Y, Liu Y B, Tang Y Z*, Cheng H*, Li S Y*. Photodynamic therapy initiated ferrotherapy of self-delivery nanomedicine to amplify lipid peroxidation via GPX4 inactivation. ACS Appl. Mater. Interfaces 2022, 14, 53501-53510.
14. Zhao L P†, Zheng R R†, Chen H Q, Liu L S, Zhao X Y, Liu H H, Qiu X Z, Yu XY*, Cheng H*, Li S Y*. Self-delivery nanomedicine for O2-economized photodynamic tumor therapy. Nano Lett. 2020, 11, 2062-2071.
15. Zhao L P†, Zheng R R†, Huang J Q, Chen X Y, Deng F A, Liu Y B, Huang C Y, Yu X Y*, Cheng H*, Li S Y*. Self-delivery photo-immune stimulators for photodynamic sensitized tumor immunotherapy. ACS Nano 2020, 14, 17100-17113.