薛勤,女,37岁,广州医科大学,药学院,副教授。留美博士及博士后,广东省“千百十计划”校级培养对象,广东省优秀青年教师培养对象。2011年以“广州市人才引进”进入广州医科大学药理教研室任副教授,担任教学和科研工作。主持及参与国家自然科学基金等多项课题,并先后在Cardiovascular Research等SCI学术期刊发表学术论文11篇,主要研究妊娠期宫内环境改变(如妊娠期缺氧、肥胖、糖尿病)对子代心血管功能异常的作用及表观遗传机制。
联系邮箱:xueqin1980@hotmail.com
研究方向:心血管药理
主要科研项目及成果:
1)雌激素改善孕期肥胖致子代心功能异常及其表观遗传机制,广东省教育厅,YQ2015137,2016-2018,项目负责人;
2)血管紧张素II受体在孕期肥胖影响子代心功能中的作用及机制,国家自然科学基金委,81200484,2013-2015,项目负责人;
3)孕期肥胖对子代心肌缺血再灌注损伤的影响及机制,市教育局,1201410365,2015-2017,项目负责人;
4)血管紧张素II受体在孕期肥胖对子代心肌缺血再灌注损伤影响中的作用及机制研究,132003,教育部,2013,项目负责人。
5)人才启动项目,2012,项目负责人。
主要论文及著作:
1) Xue Q*, Chen P, Li X, Zhang G, Patterson AJ, Luo J*. Maternal High-Fat Diet Causes a Sex-Dependent Increase in AGTR2 Expression and Cardiac Dysfunction in Adult Male Rat Offspring. Biol Reprod. 93(2):49, 2015.
2) Xue Q, Xiao D, Zhang L. Estrogen Regulates Angiotensin II Receptor Expression Patterns and Protects the Heart from Ischemic Injury in Female Rats. Biol Reprod. 93(1):6, 2015.
3) Xue Q, Patterson AJ, Xiao D, Zhang L. Glucocorticoid modulates angiotensin II receptor expression patterns and protects the heart from ischemia and reperfusion injury. PLoS One. 29;9(9):e106827, 2014.
4) Xue Q, Dasgupta C, Chen M, and Zhang L. Fetal hypoxia increases cardiac AT2R expression and subsequent vulnerability to adult ischemic injury. Cardiovasc Res.,89(2):300-308,2011.
5) Xue Q, Zhang L. Prenatal hypoxia causes a sex-dependent increase in heart susceptibility to ischemia and reperfusion injury in adult male offspring: role of protein kinase C epsilon. J Pharmacol Exp Ther.,330(2):624-632,2009.
6) Xue Q, Ducsay CA, Longo LD, Zhang L. Effect of long-term high-altitude hypoxia on fetal pulmonary vascular contractility. J Appl Physiol.,104(6):1786-1792,2008.
7) Xiao D, Huang X, Xue Q, Zhang L. Antenatal hypoxia induces programming of reduced arterial blood pressure response in female rat offspring: role of ovarian function. PLoS One. 9(6):e98743, 2014.
8) Gonzalez-Rodriguez P Jr, Tong W, Xue Q, Li Y, Hu S, Zhang L. Fetal hypoxia results in programming of aberrant angiotensin ii receptor expression patterns and kidney development. Int J Med Sci., 10(5):532-8, 2013.
9) Tong W, Xue Q, Li Y, Zhang L. Maternal hypoxia alters matrix metalloproteinase expression patterns and causes cardiac remodeling in fetal and neonatal rats. Am J Physiol Heart Circ Physiol, 301(5):H2113-H2121,2011.
10) atterson AJ, Chen M, Xue Q, Xiao D, Zhang L. Chronic prenatal hypoxia induces epigenetic programming of PKC{varepsilon} gene repression in rat hearts. Circ Res., 107(3):365-373,2010.
Lawrence J, Xiao D, Xue Q, Rejali M, Yang S, Zhang L. Prenatal nicotine exposure increases heart susceptibility to ischemia/reperfusion injury in adult offspring. J Pharmacol Exp Ther., 324(1):331-341, 2008.