李楚文

教育和工作经历：

2018年12月至今 广州医科大学，药学院 副教授

2014年8月至2018年10月 澳门大学，中华医药研究院，博士

2011年9月至2014年6月  广州中医药大学，中药学院 硕士

2007年9月至2011年6月 广州中医药大学，中药学院 学士

联系方式：lichuwen@gzhmu.edu.cn

研究方向：调控小胶质细胞表型极化的神经保护剂的活性筛选和机制研究。改善焦虑抑郁行为及卒中脑损伤的中药活性成分筛选和作用机制研究。

近期研究成果：

1. Wu X, Deng M, Gao Z, Dang Y, Li Y#, Li C#, Neferine alleviates memory and cognitive dysfunction in diabetic mice through modulation of the NLRP3 inflammasome pathway and alleviation of endoplasmic-reticulum stress. Int Immunopharmacol 2020; 84.

2. Zhuo J, Chen B, Sun C, Jiang T, Chen Z, Liu Y, Nie J, Yang H, Zheng J, Lai X, Su Z, Li C#, Li Y#, Patchouli alcohol protects against chronic unpredictable mild stress-induced depressant-like behavior through inhibiting excessive autophagy via activation of mTOR signaling pathway. Biomed Pharmacother 2020; 127.

3. Wu X, Tang B, Liao X, Su Z, Lee SM, Cai Y, Li C#, Suppressive effects of the supercritical-carbon dioxide fluid extract of Chrysanthemum indicum on chronic unpredictable mild stress-induced depressive-like behavior in mice. Food Funct 2019; 10,1212-1224.

4. Li C#, Deng M, Gao Z, Dang Y, Zheng G, Yang X, Chao Y, Cai Y, Wu X#, Effects of compound K, a metabolite of ginsenosides, on memory and cognitive dysfunction in db/db mice involve the inhibition of ER stress and the NLRP3 inflammasome pathway. Food Funct 2020; 11, 4416-4427.

5. Li C, Bian Y, Feng Y, Tang F, Wang L, Hoi MPM, Ma D, Zhao C, Lee SMY#, Neuroprotective Effects of BHDPC, a Novel Neuroprotectant, on Experimental Stroke by Modulating Microglia Polarization. ACS Chem Neurosci 2019; 10,2434-2449.

6. Li C, Chen T, Zhou H, Feng Y, Hoi MPM, Ma D, Zhao C, Zheng Y, Lee SMY#. BHDPC Is a Novel Neuroprotectant That Provides Anti-neuroinflammatory and Neuroprotective Effects by Inactivating NF-kappaB and Activating PKA/CREB. Front Pharmacol 2018; 9,614.

7. Li C, Zhang C, Zhou H, Feng Y, Tang F, Hoi MPM, He C, Ma D, Zhao C, Lee SMY#, Inhibitory Effects of Betulinic Acid on LPS-Induced Neuroinflammation Involve M2 Microglial Polarization via CaMKKbeta-Dependent AMPK Activation. Front Mol Neurosci 2018; 11,98.

8. Li C, Tang B, Feng Y, Tang F, Pui-Man Hoi M, Su Z, Ming-Yuen Lee S#, Pinostrobin Exerts Neuroprotective Actions in Neurotoxin-Induced Parkinson's Disease Models through Nrf2 Induction. J Agric Food Chem 2018; 66,8307-8318.

9. Zhang C, Li C, Chen S, Li Z, Jia X, Wang K, Bao J, Liang Y, Wang X, Chen M, Li P, Su H, Wan J, Lee S, Liu K, He C, Berberine protects against 6-OHDA-induced neurotoxicity in PC12 cells and zebrafish through hormetic mechanisms involving PI3K/AKT/Bcl-2 and Nrf2/HO-1 pathways. Redox Biol 2017; 11, 1-11.

10. Chen T, Li C, Li Y, Yi X, Wang R, Lee S, Zheng Y, Small-Sized mPEG-PLGA Nanoparticles of Schisantherin A with Sustained Release for Enhanced Brain Uptake and Anti-Parkinsonian Activity. ACS Appl Mater Inter 2017; 9, 9516-9527.