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冯森玲



    冯森玲,副研究员,药学硕士研究生导师。博士毕业于澳门科技大学,2019年于广州医科大学附属第三医院工作。广州市科技专家库入库专家,药物治疗管理服务(MTMs)认证药师。世界中联中医药免疫专业委员会理事、广东省药学会第二届药学科普专家委员会常务委员、广东省中医药学会中药药剂与药理专业委员会委员。Traditional Medicine Research、World Journal of Gastroenterology、Frontiers in PharmacologyJournal of Exploratory Research in Pharmacology、山东医药等杂志编委及审稿专家。


【联系邮箱】slfeng@gzhmu.edu.cn;slfengmust@163.com


【研究方向类别】

1、学术学位:药理学

2、专业学位:临床药学(临床药理学)


【具体研究方向 肿瘤耐药及药物抗肿瘤药理


【主要科研项目】

1.国家自然科学基金-青年基金,82104446,主持

2.广东省自然科学基金面上项目,2023A1515011961,主持

3.广东省基础与应用基础区域联合基金,2019A1515111109,主持,结题

4.广东省教育厅普通高校特色创新项目,2022KTSCX100,主持

5.广州市科技局市校(院)联合基础研究项目,SL2023A03J00851,主持


【所获荣誉和奖励】

1.广州医科大学附属第三医院“毅文人才工程”计划

2.澳门特别行政区科技研发奖


【主要论文及著作(代表性)】

1. Yuqin Yin1, Y U Wu1, Hongliang Huang, Yingying Duan, Zhongwen Yuan, Lihui Cao, Jinjin Ying, Yongheng Zhou*, Senling Feng*. The superiority of PMFs on reversing drug resistance of colon cancer and the effect on aerobic glycolysis-ROS-autophagy signaling axis. Oncology research, 2024, 32 (12): 1891-1902.

2. Feng Senling1, Li Yuting1, Huang Hanhui1, Huang Hongliang, Duan Yingying, Yuan Zhongwen, Zhu Wenting, Mei Zhengrong, Luo Lianxiang*, Yan Pengke*. Isoorientin reverses lung cancer drug resistance by promoting ferroptosis via the SIRT6/Nrf2/GPX4 signaling pathway. European journal of pharmacology, 2023, 954 175853.

3. Xie Ying1,Feng SenLing1,He Fang,Yan PeiYu,Yao XiaoJun,Fan XingXing,Leung Elaine LaiHan*,Zhou Hua*. Down-regulating Nrf2 by tangeretin reverses multiple drug resistance to both chemotherapy and EGFR tyrosine kinase inhibitors in lung cancer. Pharmacological research,2022,186,106514.

4. Senling Feng1; Huifang Zhou1; Deyan Wu; Dechong Zheng; Biao Qu; Ruiming Liu; Chen Zhang; Zhe Li; Ying Xie*; Hai-Bin Luo*. Nobiletin and its derivatives overcome multidrug resistance (MDR) in cancer: total synthesis and discovery of potent MDR reversal agents[J].Acta Pharmaceutica Sinica B,2020,10(2):327-343.

5. Sen-Ling Feng, Hai-Bin Luo, Liang Cai, Jie Zhang, Dan Wang, Ying-Jiang Chen, Huan-Xing Zhan, Zhi-Hong Jiang, Ying Xie*. Ginsenoside Rg5 overcomes chemotherapeutic multidrug resistance mediated by ABCB1 transporter: in vitro and in vivo study. Journal of Ginseng Research, 2020, 44 (2): 247-257.

6. Sen-Ling Feng1, Yun Tian1, Shuai Huo1, Biao Qu, Rui-Ming Liu, Peng Xu, Ya-Zhuo Li*, Ying Xie*. Nobiletin potentiates paclitaxel anticancer efficacy in A549/T xenograft model: Pharmacokinetic and pharmacological study. Phytomedicine, 2020, 67 (C): 153141.


【专利】

1.冯森玲,袁中文,严鹏科,黄鸿亮,朱雯婷. 专利号:ZL202210335305.2,异荭草素联合顺铂在制备逆转肺癌耐药的药物中的应用。

2.袁中文,冯森玲, 严鹏科. 专利号:ZL202010464568.4,一种治疗非酒精性脂肪肝的组合物及用途。

3.Ma WZ,Feng SL, Yao XJ, Yuan ZW, Liu L, Xie Y. Use of tangeretin in cancer treatment. U.S. Patent No. 9,808,439.