【个人简介】

林水木，男，博士，福建漳州人，药学院教授，博士生导师，“南山学者”骨干人才。本硕博均就读于华南理工大学，博士期间（2016-2018年）于新加坡眼科研究所开展联合培养，2012-2015年任职于新加坡眼科研究所，担任Research Associate。针对目前缺乏新型抗耐药菌药物等关键科学问题，课题组融合药物化学、化学生物学、药理学、毒理学、基因组学和蛋白组学等多学科技术，通过仿生模拟抗菌肽、对天然产物的修饰改性和基于结构的药物设计等策略开展first-in-class及best-in-class类抗耐药菌新药的发现研究，助力解决微生物耐药性难题。课题组核心研究方向为药物化学、抗感染新药研发和生物标志物的检测。以第一或通讯作者在Sci Adv, J Adv Res, Acc Chem Res, J Med Chem (11篇), Eur J Med Chem (7篇), Sensor Actuat B-Chem等期刊上发表SCI论文40余篇。2021年作为第一兼通讯作者应邀在化学顶级期刊Acc Chem Res上撰写关于黄酮类抗菌拟肽的综述论文。获授权中国发明专利7项，美国和韩国发明专利各1项；国际PCT专利2项。其中作为第一发明人的关于补骨脂酚类抗菌药物的专利于2021年成功转让给药企（51万），由药企进行系统的临床前开发。

【联系邮箱】

linshuimu020@163.com；linshuimu@gzhmu.edu.cn.

【研究方向类别】

1、学术学位：

药物化学

2、专业学位：

工业药学（转化药学）

【具体研究方向】

1) 创新抗感染新药的设计开发

2) 天然产物的结构修饰和改性研究

【主要科研项目】

1) 广州医科大学高水平大学建设人才启动项目(B195002009030，100万)

2) 国家自然科学基金青年项目(21907019，27万)

3) 广州医科大学附属第六医院开放课题项目（202301-308，20万）

4) 广州医科大学药学院省部级重点实验室开放课题（J24413001，8万）。

5) 广州医科大学科研能力提升项目（01-410-250242，15万）

【所获荣誉和奖励】

1）指导（第一指导教师）的本科生团队于2023年参加由全国药学类院校大学生专业技术与实验技能竞赛组委会主办的第十四届“全国大学生药苑论坛”，斩获“创新成果一等奖”和“优秀论文奖”。

2）指导3名研究生获得校级优秀硕士学位论文。

3）培养6名硕士生分别进入新加坡南洋理工大学（2名），北京大学，广州实验室，广州医科大学和南方医科大学攻读博士学位。

【主要论文及著作（代表性）】

代表性第一和通讯作者论文（2020年至今）：

(1) Suhua Wu, Venkatesh Mayandi, Eunice Tze Leng Goh, Wenyi Wang, Nuotong Han, Rongcui Zhong, Yue Wang, Mu Chen, Rajamani Lakshminarayanan*, Zhixiong Ruan*, Shouping Liu*, Shuimu Lin*, Boronic acid derivatives inhibit Candida albicans growth by compromising energy metabolism. Journal of Advanced Research, 2025 Jul 28:S2090-1232(25)00573-9. (中科院一区, IF=13.0)

(2) Li Haizhou¹, Kang Wen-Tyng^1,*, Zheng Yujiahui, He Yonglv, Zhong Rongcui, Fang Shanfang, Wen Weijie, Liu Shouping*, Lin Shuimu*, Development of xanthone derivatives as effective broad-spectrum antimicrobials: Disrupting cell wall and inhibiting DNA synthesis. Science Advances, 2025，11, eadt4723. (中科院一区, IF=12.5)

(3) Lin, Shuimu^*; Wade, John D. ^*; Liu, Shouping^*; De Novo Design of Flavonoid-Based Mimetics of Cationic Antimicrobial Peptides: Discovery, Development, and Applications, Accounts of Chemical Research, 2021, 54(1): 104-119. (中科院一区, IF=17.7)

(4) Cai, Qiongna¹; Yu, qian¹; Liang, Wanxin; Li, Haizhou; Liu, Jiayong; Li, Hongxia; Chen, Yongzhi; Fang, Shanfang; Zhong, Rongcui; Liu, Shouping^*; Lin, Shuimu^*. Membrane-Active Nonivamide Derivatives as Effective Broad-Spectrum Antimicrobials: Rational Design, Synthesis, and Biological Evaluation. Journal of Medicinal Chemistry, 2022, 65(24), 16754-16773. (中科院一区, IF=6.8)

(5) Liang, Wanxin; Yu, qian; Zheng, Zixian; Liu, Jiayong; Cai, Qiongna; Liu, Shouping^*; Lin, Shuimu^*; Design and Synthesis of Phenyl Sulfide-Based Cationic Amphiphiles as Membrane-Targeting Antimicrobial Agents against Gram-Positive Pathogens, Journal of Medicinal Chemistry, 2022, 65(20):14221-14236. (中科院一区, IF=6.8)

(6) Liu, Jiayong^#; Li, Hongxia^#; Li, Haizhou; Fang, Shanfang; Shi, Jinguo; Chen, Yongzhi; Zhong, Rongcui; Liu, Shouping^*; Lin, Shuimu^*; Rational Design of Dipicolylamine-Containing Carbazole Amphiphiles Combined with Zn²⁺ as Potent Broad-Spectrum Antibacterial Agents with a Membrane-Disruptive Mechanism, Journal of Medicinal Chemistry, 2021, 64(14): 10429-10444 (中科院一区, IF=6.8)

(7) Li, Hongxia^#; Liu, Jiayong^#; Liu, Chuan-Fa; Li, Haizhou; Luo, Jiachun; Fang, Shanfang; Chen, Yongzhi; Zhong, Rongcui; Liu, Shouping^*; Lin, Shuimu^*; Design, Synthesis, and Biological Evaluation of Membrane-Active Bakuchiol Derivatives as Effective Broad-Spectrum Antibacterial Agents, Journal of Medicinal Chemistry, 2021, 64(9): 5603-5619. (中科院一区, IF=6.8)

(8) Lin, Shuimu; Li, Hongxia; Tao, Yiwen; Liu, Jiayong; Yuan, Wenchang; Chen, Yongzhi; Liu, Ying; Liu, Shouping^*; In Vitro and in Vivo Evaluation of Membrane-Active Flavone Amphiphiles: Semisynthetic Kaempferol-Derived Antimicrobials against Drug-Resistant Gram-Positive Bacteria, Journal of Medicinal Chemistry, 2020, 63(11): 5797-5815. (中科院一区, IF=6.8)

(9) Lin, Shuimu; Liu, Jiayong; Li, Hongxia; Liu, Ying; Chen, Yongzhi; Luo, Jiachun; Liu, Shouping^*; Development of Highly Potent Carbazole Amphiphiles as Membrane-Targeting Antimicrobials for Treating Gram-Positive Bacterial Infections, Journal of Medicinal Chemistry, 2020, 63(17): 9284-9299. (中科院一区, IF=6.8)

(10) He Wang^#, Shuimu, Lin^#, Jiacui Xie, Xuming Chen, Yating Deng, Pei Huang, Kanglong Peng, Wenhui Gao, Guodong Ye, Guihua Wang, Xiyong Yu, Huaying Wen*, Linghao Qin*, Yi Zhou*. Chondroitin sulfate nanoparticles based on co-delivery dual drug induced ferroptosis in lung cancer cells by disrupting mitochondrial oxidative homeostasis. Mater. Today Bio. 2025, 31, 101632. (中科院1区, IF=10.2)

(11) Wenyan Xu^#, Chengwei Zheng^#, Mu Chen^#, Xin Deng^#, Lingmin Zhang, Xueping Lei, Lu Liang, Xiyong Yu, Xinwei Hu^*, Juyun He^*, Shuimu Lin^*, Zhixiong Ruan^*. Modular Synthesis of Bioactive Selenoheterocycles for Efficient Cancer Therapy via Electrochemical Selenylation/Cyclization. Journal of medicinal chemistry, 2025, 68(6), 6339–6360. (中科院一区, IF=6.8)

(12) Rongcui Zhong, Lingqing Xu, Jiaxuan Wu, Mengyi He, Suhua Wu, Zhaozu Luo, Nuotong Han, Yongyi Yao, Jing Zhou, Zhixiong Ruan^*, Shouping Liu^*, Shuimu Lin^*. Rational design of ivacaftor-derived antimicrobial peptidomimetics: Membrane-targeting strategy enhances broad-spectrum antimicrobial efficacy against MDR pathogens. European Journal of Medicinal Chemistry, 2025, 302, 118290. (中科院一区, IF=5.9)

(13) Zhong, Rongcui; Xu Zikai, Zhang Shujun, Zeng Minghui, Li Haizhou, Liu, Shouping^*; Lin, Shuimu^*. Development of novel bisphenol derivatives with a membrane-targeting mechanism as potent gram-positive antibacterial agents. European Journal of Medicinal Chemistry, 2024, 274, 116544. (中科院一区, IF=5.9)

(14) Fang, Shanfang; Kang, W. T.; Li, Haizhou; Cai, Qiongna; Liang, Wanxin; Zeng, Minghui; Yu, Qian; Zhong, Rongcui; Tao, Yiwen; Liu, Shouping^*; Lin, Shuimu^*. Development of cannabidiol derivatives as potent broad-spectrum antibacterial agents with membrane-disruptive mechanism. European Journal of Medicinal Chemistry, 2024, 266, 116149. (中科院一区, IF=5.9)

(15) Yu, Qian; Cai, Qiongna; Liang, Wanxin; Zhong, Kewen; Liu, Jiayong; Li, Haizhou; Chen, Yongzhi; Li, Hongxia; Fang, Shanfang; Zhong, Rongcui; Liu, Shouping^*; Lin, Shuimu^*. Design of phenothiazine-based cationic amphiphilic derivatives incorporating arginine residues: Potential membrane-active broad-spectrum antimicrobials combating pathogenic bacteria in vitro and in vivo. European Journal of Medicinal Chemistry, 2023, 260, 115733. (中科院一区, IF=5.9)

(16) Liu, Jiayong; Li, Hongxia; He, Qile; Chen, Kaiting; Chen, Yongzhi; Zhong, Rongcui; Li, Haizhou; Fang, Shanfang; Liu, Shouping^*; Lin, Shuimu^*; Design, synthesis, and biological evaluation of tetrahydroquinoline amphiphiles as membrane-targeting antimicrobials against pathogenic bacteria and fungi, European Journal of Medicinal Chemistry, 2022, 243: 114734. (中科院一区, IF=5.9)

(17) Chen, Yongzhi; Li, Hongxia; Liu, Jiayong; Zhong, Rongcui; Li, Haizhou; Fang, Shanfang; Liu, Shouping^*; Lin, Shuimu^*; Synthesis and biological evaluation of indole-based peptidomimetics as antibacterial agents against Gram-positive bacteria, European Journal of Medicinal Chemistry, 2021, 226: 113813. (中科院一区, IF=5.9)

(18) Lin, Shuimu^#; Chen, Yongzhi^#; Li, Hongxia; Liu, Jiayong; Liu, Shouping^*; Design, synthesis, and evaluation of amphiphilic sofalcone derivatives as potent Gram-positive antibacterial agents, European Journal of Medicinal Chemistry, 2020, 202: 112596. (中科院一区, IF=5.9)

主要授权专利：

1) 林水木，刘寿平，栗宏霞，江鸿；补骨脂酚衍生物、其药学上可接受的盐及其制备方法和应用；授权号：ZL202011152645.9，授权日：2022-11-15。同时申请国际PCT专利，申请号：PCT/CN2020/125481，申请日期：2020-10-27，目前已进入欧洲、日本、菲律宾、印尼和新加坡等国家申请阶段。（已转让）

2) 林水木，刘寿平，栗宏霞；黄酮类化合物及其制备方法和应用；授权号：ZL201911257926.8，授权日：2023-2-17。

3) 林水木，刘寿平，梁婉欣；二苯硫醚化合物、抗菌药物及制备方法与应用；授权号：ZL202210322575X；授权日：2023-06-06。

4) 林水木，刘寿平，刘家勇；氯福克酚衍生物、抗菌药物及制备方法与应用；授权号：ZL202210427128.0；授权日：2023-11-03。（同时提交国际PCT发明专利申请，申请号：PCT/CN2022/088513，申请日期：2022-04-22。）

5) 林水木，刘寿平，栗宏霞，江鸿；补骨脂酚衍生物、其药学上可接受的盐及其制备方法和应用；美国授权号：US 11,912,650B2，授权日：2024-02-27。

6) 林水木，刘寿平，栗宏霞，江鸿；补骨脂酚衍生物、其药学上可接受的盐及其制备方法和应用；韩国授权号：10-2630858，授权日：2024-01-24。

7) 刘颖，林水木，刘寿平，张淑君；四苯乙烯衍生物及其应用；授权号：ZL202410633326.1，授权日：2025-02-21。

8) 刘颖，林水木，刘寿平，许梓锴；巯基苯酚衍生物及其应用；授权号：ZL202410633328.0，授权日：2025-03-11。

9) 阮志雄，徐中楠，林水木，要记文；偕二硒类化合物及其合成方法和应用；授权号：ZL202211185852.3，授权日：2023-10-03。