孙平，男，副研究员，本科毕业于四川大学生物工程专业，博士毕业于德国维尔茨堡大学（Julius-Maximilians-Universität Würzburg）医学院生命科学专业近几年来主要从事抗炎小分子化合物筛选与其药理机制和靶点研究，从小分子化合物库筛选新型NLRP3炎症小体抑制剂和器官纤维化抑制剂，检测化合物在肺纤维化、急性肺损伤、银屑病、痛风等炎症相关疾病中的药效和药理机制，选择合适的先导化合物进行结构优化（与药化团队合作），发现新的炎症性疾病候选药物。

联系邮箱：josp124@foxmail.com

研究方向：抗炎免疫药理学

主要科研项目及成果：

1. 神经炎症抑制剂AD16对阿尔茨海默病模型APP/PS1双转基因小鼠脑内成体神经再生的影响及机制研究，广东省自然科学基金，2017.1.1-2020.4.1 主持

2. 广州市基础与应用基础研究一般项目，小分子AD110通过上调IL-10改善小胶质细胞代谢功能从而抑制AD发病的作用与机制研究，2020.1.1-2022.12.31，主持

3. 神经胶质细胞调节剂AD110 延缓阿尔茨海默氏症的作用及机制研究，国家自然科学基金，2019.1-2022.12 参与

近5年主要论文及著作：

(1). Zhou Y#, Yang Z#, Ou Y, Cai H, Liu Z, Lin G, Liang S, Hua L, Yan Y, Zhang X, Wu R, Qin A, Hu W*, Sun P*. Discovery of a selective NLRP3-targeting compound with therapeutic activity in MSU-induced peritonitis and DSS-induced acute intestinal inflammation. Cellular and Molecular Life Sciences. 2023 Jul 27;80(8):230. （通讯）

(2). Deng W#, Yang Z#, Yue H, Ou Y, Hu W*, Sun P*. Disulfiram suppresses NLRP3 inflammasome activation to treat peritoneal and gouty inflammation. Free Radical Biology and Medicine, 2020 May 152:8-17. （通讯）

(3). Chen X#, Chen Y#, Ou Y, Min W, Liang S, Hua L, Zhou Y, Zhang C, Chen P, Yang Z*, Hu W*, Sun P*. Bortezomib inhibits NLRP3 inflammasome activation and NF-κB pathway to reduce psoriatic inflammation. Biochemical Pharmacology, 2022 Dec, 206:115326. （通讯）

(4). Chen Y#, Chen X#, Liang S, Ou Y, Lin G, Hua L, Wu X, Zhou Y, Liu Z, Cai H, Yang Z*, Hu W*, Sun P*. Chlorquinaldol inhibits the activation of nucleotide-binding oligomerization domain-like receptor family pyrin domain-containing protein 3 inflammasome and ameliorates imiquimod-induced psoriasis-like dermatitis in mice. Chemico-Biological Interactions, 2022 Sep 25;365:110122. （通讯）

(5). Liang S#, Yang Z#, Hua L, Chen Y, Zhou Y, Ou Y, Chen X, Yue H, Yang X, Wu X, Hu W*, Sun P*. Ciclopirox inhibits NLRP3 inflammasome activation via protecting mitochondria and ameliorates imiquimod-induced psoriatic inflammation in mice. European Journal of Pharmacology. 2022 Sep 5;930:175156.（通讯）

(6). Wu X#, Sun P#, Chen X, Hua L, Cai H, Liu Z, Zhang C, Liang S, Chen Y, Wu D, Ou Y, Hu W*, Yang Z*. Discovery of a Novel Oral Proteasome Inhibitor to Block NLRP3 Inflammasome Activation with Anti-inflammation Activity. Journal of Medicinal Chemistry. 2022 Sep 5, 65, 18, 11985–12001 （共一作）

(7). Hao Y, Ou Y, Zhang C, Chen H, Yue H, Yang Z, Zhong X, Hu W*, Sun P*. Seratrodast, a thromboxane A2 receptor antagonist, inhibits neuronal ferroptosis by promoting GPX4 expression and suppressing JNK phosphorylation. Brain Research. 2022 Nov 15;1795:148073. （通讯）

(8). Huang X#, Sun P#, Qin Y#, Wang X, Wang M, Lin Y, Zhou R, Hu W, Liu Q*, Yu X*, Qin A*. Disulfiram attenuates MCMV-Induced pneumonia by inhibition of NF-κB/NLRP3 signaling pathway in immunocompromised mice. International Immunopharmacology, 2022, February 103(11):108453.（共同一作）

(9). Yue H, Yang Z, Ou Y, Liang S, Deng W, Chen H, Zhang C, Hua L, Hu W*, Sun P*. Tanshinones inhibit NLRP3 inflammasome activation by alleviating mitochondrial damage to protect against septic and gouty inflammation. International Immunopharmacology, 2021, June 97(7):107819.（通讯）

(10). Sun P, Yue H, Xing Q, Deng W, Ou Y, Pan G, Zhong X*, Hu W*. Compound AD16 reduces amyloid plaque deposition and modifies microglia in a transgenic mouse model of Alzheimer's disease. ACS Pharmacology & Translational Science, 2020, Nov 3(6) 1100-1110.

(11). Sun P#, Zhou W#, Yue H, Zhang C, Ou Y, Yang Z*, Hu W*. Compound AD110 acts as therapeutic management for Alzheimer's disease and stroke in mouse and rat models. ACS Chemical Neuroscience, 2020 Mar 11(6):929-938.

(12). Zhang C#, Yue H#, Sun P#, Hua L, Liang S, Ou Y, Wu D, Wu X, Chen H, Hao Y, Hu W*, Yang Z*. Discovery of Chalcone Analogues as Novel NLRP3 Inflammasome Inhibitors with Potent Anti-inflammation Activities. European Journal of Medicinal Chemistry. 2021 April 219:113417. （共同一作）

(13). Chen H#, Chen X#, Sun P#, Wu D, Yue H, Pan J, Li X, Zhang C, Wu X, Hua L, Hu W*, Yang Z*. Discovery of dronedarone and its analogues as NLRP3 inflammasome inhibitors with potent anti-inflammation activity. Bioorganic & Medicinal Chemistry Letters, 2021 May 46:128160. （共同一作）

(14). Ou Y#, Sun P#, Wu N#, Chen H, Wu D, Hu W*, Yang Z*. Synthesis and biological evaluation of parthenolide derivatives with reduced toxicity as potential inhibitors of the NLRP3 inflammasome. Bioorganic & Medicinal Chemistry Letters, 2020, July 127399 （共同一作）

(15). Hua L, Liang S, Zhou Y, Wu X, Cai H, Liu Z, Ou Y, Chen Y, Chen X, Yan Y, Wu D, Sun P, Hu W, Yang Z. Artemisinin-derived artemisitene blocks ROS-mediated NLRP3 inflammasome and alleviates ulcerative colitis. Int Immunopharmacol. 2022 Dec;113(Pt B):109431. （共通讯排第三）

(16). Sun P, Ortega G, Tan Y, Hua Q, Riederer PF, Deckert J, Schmitt-Böhrer AG*. Streptozotocin impairs proliferation and differentiation of adult hippocampal neural stem cells in vitro-correlation with alterations in the expression of proteins associated with the insulin system. Frontiers in Aging Neuroscience, 2018 May 18;10:145.

(17). 胡文辉、余细勇、孙平、赵昕、吴波；嘧啶哌嗪酰胺类化合物及其应用；专利号：ZL201710591660.5；授权日：2019.9.19

(18). 胡文辉、杨忠金、孙平、陈浩、陈秀会；苯并呋喃类化合物及其应用；专利号：ZL202110513101.9；授权日：2022.11.15

(19). 胡文辉、杨忠金、孙平、张成、岳虎；1，3-二苯基丙-2-烯-1-酮衍生物及其应用；专利号：ZL202110317148.8；授权日：2022.12.17