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黄洋

【个人简介】

黄洋,男,湖北汉川人,硕士研究生导师,副研究员,分别于2017年12月获取暨南大学(中药化学专业)和比利时列日大学(生物医学与制药科学)双博士学位;后于2018年4月在深圳市药品检验研究院和中国药科大学从事博士后研究;并于2020年6月入职广州医科大学药物分析教研室。目前从事的主要研究方向为中药质量评价与控制,中药药效物质基础,中药活性筛选方面等方面的研究。近年来在国内外学术期刊发表论文43篇,其中以第一作者或通讯作者SCI论文22篇;成功授权中国发明专利2项,PCT专利1项和欧洲专利1项(ZL201910913203.2,ZL201910778184.7,PCT/CN2020/083729,EP3907493 A1)。主持博士后科学基金面上项目(2018M643205),深圳市基础研究面上项目(JCYJ20190806171605522)和广州市基础与应用基础研究项目(202102020516)各1项,广州医科大学科研能力提升起步项目等,参与国家级课题多项;深圳市留学回国人员(2018),广州市青年后备人才(2022);相关学术报告或论文屡次获奖,如二十七届国际生物药物分析大会最佳poster二等奖,十一届全国药分大会优胜报告奖,深圳药学会优秀论文一等奖,全国药物分析论坛在校学生优秀论文三等奖等。目前担任广东省药学会第二届生物医药分析专业委员会常务委员,广东省药学会第十二届药物分析专业委员会副主任委员,Phytotherapy Research,Chromatographia,Natural Product Research,Journal of Pharmaceutical and Biomedical Analysis,Journal of Separation Science等多个杂志审稿人,Frontiers in Analytical Science编委等。


【联系邮箱】

huangyang@gzhmu.edu.cn

【研究方向  

中药活性筛选;中药药效物质基础研究;中药质量评价与控制;超临界流体色谱等现代仪器分析;生物传感方向

【主要科研项目】

1. 广州市科技局,基础与应用基础研究项目,基于AD活性的中药功劳木质量的化学模式识别研究,2021-4至2023-3,5万,结题,主持;

2. 深圳市科技创新委员会,面上项目,JCYJ20190806171605522,中药功劳木抗乙酰胆碱酯酶活性成分的量效关系及初步作用机理研究,2020-5至2023-5,30万,结题,主持;

3. 中国博士后科学基金会,面上项目,2018M643205,中药功劳木抗AD活性物质全在线筛选及质量控制,2018-11至2020-05,5万,已结题,主持;

4. 国家自然科学基金委员会,面上项目,81673391,基于免抗体亲和富集技术的体内单抗药物精准定量分析方法研究,2016-01至2019-12,70万,已结题,参与;

5. 国家自然科学基金委员会,青年项目,81503030,基于亲和整体柱的药物选择性杀伤MDR肿瘤细胞靶标蛋白的垂钓研究,2015-01至2017-12,17.9万,已结题,参与;

6. 国家自然科学基金委员会,青年项目,81503031,基于LasR受体在线筛选中药黄芩中细菌生物膜抑制活性成分研究,2015-01至2017-12,17.9万,已结题,参与;


【所获荣誉和奖励】

2016年获比利时列日大学Erasmus+ International credit Mobility scholarship

2016年第27届国际药物分析和生物药物分析年会poster二等奖

2017年《中国药学会》岛津杯第十三届全国药物分析论坛在校学生优秀论文三等奖

2018年深圳药学会优秀论文一等奖

2019年深圳药学会优秀论文三等奖


【主要论文及著作(代表性)】

[1] Y. Huang, Z.J. Jiang, J. Wang, G. Yin, K. Jiang, J.S. Tu*, T.J. Wang*. Quality evaluation of Mahonia bealei (Fort.) Carr. using supercritical fluid chromatography with chemical pattern recognition, Molecules, 2019 (24): 3684-3696.

[2] Y. Huang, T.J. Wang*, G. Yin, J. Wang, K. Jiang, J.S. Tu*. Quality evaluation of Mahonia bealei (Fort.) Carr. by high performance liquid chromatography with chemical pattern recognition, Journal of Separation Science, 2020 (43): 3625-3635.

[3] Y. Huang*, T.J. Wang*, Z.J. Jiang. Fast analysis of alkaloids from different parts of Mahonia bealei (Fort.) Carr studied for their anti-Alzheimer’s activity using supercritical fluid chromatography, Journal of Separation Science, 2021, 44(9):2006-2014.

[4] Y. Huang, Y. Su, T.J. Wang*. Cultivars of Mahonia bealei (Fort.) Carr. as a source of potential natural product with anti-Alzheimer's Disease activity, Frontiers Drug, Chemistry and Clinical Research, 2021 (4): 1-7.

[5] Y. Huang, T.J. Wang*, J. Wang, G. Yin, J.S. Tu*. Ligand fishing and identification of acetylcholinesterase inhibitors in Mahonia bealei (Fort.) Carr. using high performance liquid chromatography-mass spectrometry, Journal of Liquid Chromatography & Related Technology, 2020 (43): 538-546.

[6] Y. Huang, T.J. Wang, M. Fillet, J. Crommen, Z.J. Jiang*. Simultaneous determination of amino acids in different teas using supercritical fluid chromatography coupled with single quadrupole mass spectrometry, Journal of Pharmaceutical Analysis, 2019, 9(4): 254-258.    

[7] Y. Huang, O. Jansen, M. Frédérich, A. Mouithys-Mickalad, G. Nys, A.C. Servais, J. Crommen, Z.J. Jiang, M. Fillet*. Capillary electrophoresis, high-performance liquid chromatography, and thin-layer chromatography analyses of phenolic compounds from rapeseed plants and evaluation of their antioxidant activity, Journal of Separation Science, 2019, 42(2): 609-618.

[8] Y. Huang#, T.T. Zhang#, Y.M. Zhao, H.B. Zhou, G.Y. Tang, M. Fillet, J. Crommen, Z.J. Jiang*. Simultaneously analysis of nucleobases, nucleosides and ginsenosides in ginseng extracts using supercritical fluid chromatography/mass spectrometry, Journal of Pharmaceutical and Biomedical Analysis, 2017, (144): 213-219.  

[9] Y. Huang, Y. Feng, G.Y. Tang, M.Y. Li, T.T. Zhang*, M. Fillet, J. Crommen, Z.J. Jiang*. Development and validation of a fast SFC method for the analysis of flavonoids in plant extracts, Journal of Pharmaceutical and Biomedical Analysis, 2017, (140): 384-391.  

[10] Y. Huang#, T.T. Zhang#, H.B. Zhou, Y. Feng, C.L. Fan, W.J. Chen, J. Crommen, Z.J. Jiang*. Fast separation of triterpenoid saponins using supercritical fluid chromatography coupled with single quadrupole mass spectrometry, Journal of Pharmaceutical and Biomedical Analysis, 2016, 121: 22-29.  

[11] Y. Huang#, M.J. Gou#, K. Jiang, L.J. Wang, G. Yin, J. Wang, P. Wang, J.S. Tu*, T.J. Wang*. Recent quantitative research of near infrared spectroscopy in traditional Chinese medicine analysis, Applied Spectroscopy Reviews, 2019, (54): 653-672.

[12] Y. Huang, G.Y. Tang, T.T. Zhang, M. Fillet, J. Crommen, Z.J. Jiang*, Supercritical Fluid Chromatography in Traditional Chinese Medicine Analysis, Journal of Pharmaceutical and Biomedical Analysis, 2018, (147): 65-80.

[13] G.Y. Tang#, Y. Huang#, T.T. Zhang, Q.Q. Wang, J. Crommen, M. Fillet, Z.J. Jiang*. Determination of phenolic acids in extra virgin olive oil usingsupercritical fluid chromatography coupled with single quadrupole mass spectrometry, Journal of Pharmaceutical and Biomedical Analysis, 2018, 157: 217-225.

[14] Y. Huang, K. Li*, H.K. Shao, S.Q. Liu, F.J. Xiang. Pharmacokinetic study of liquiritin in rat serum using molecularly imprinted solid-phase extraction combined with RP-HPLC. Analytical Methods, 2014, (6):1563-1568.

[15] L. Song#, Y. Huang#, M.J Gou, J. Crommen, Z.J. Jiang*, Y.F. Feng*. Method development and validation for the determination of biogenic amines in soy sauce using supercritical fluid chromatography coupled with single quadrupole mass spectrometry, Journal of separation science, 2020 ,43(13): 2728-2736.

[16]Y. Huang*, Z.J. Jiang*. Determination of saccharides in honey using supercritical fluid chromatography coupled with single quadrupole mass spectrometry, Journal of chromatographic science, 43 (2020) 538-546.

[17]Y. Huang*, Z.J. Jiang*. Supercritical fluid chromatography using methacrylate-based monolithic column for the separation of polar analytes, Journal of separation science, 2021, 44(17): 3324-3332.