胡文辉教授简介：

胡文辉，药物化学专业博士生导师，广东省“珠江学者”特聘教授，兼广州医科大学药学院学术委员会主任，研究所所长，广东省分子靶标与临床药理重点实验室副主任。

2002年毕业于中国协和医科大学药物研究所，师从郭宗儒教授，开展抗炎药物的研究，获得博士学位。2002年-2006年在美国西北大学医学院从事博士后研究，开展神经退行性疾病的药物研究。2006年-2016年在中国科学院广州生物医药与健康研究院历任副研究员、研究员、新药开发室主任。

在历时20多年的新药研究中，胡教授团队已确立多个全新结构的候选药物。其中，基于神经炎症的抗阿尔茨海默氏症新药AD16（GIBH130、哌达甲酮），已获得国家药品监督管理局（NMPA）颁发的1.1类药物临床试验批件，正在开展临床试验，化合物专利涵盖了全球多个国家。

联系邮箱：

huwenhui@gzhmu.edu.cn

研究方向：

创新药物研究

主要科研项目及成果：

立足于尚无有效药物的重大疾病，开展致病机制和创新药物的研究，确立原创（First-in-class）候选新药。截至目前，胡教授已获得授权专利30多项，主持国家科技部、国家自然科学基金委、广东省科技厅的新药重大专项，企业横向经费等各类新药研发基金2000多万元。

所获荣誉和奖励：

2011年获得广东省优秀共产党员，2014年获得广东省优秀专利奖。兼任药学学报编委、广东省药学会药物化学专业委员会副主委。

近期学术论文：

1. Xin Zhao, Runfeng Li, Yang Zhou, Mengjie Xiao, Chunlong Ma, Zhongjin Yang, Shaogao Zeng, Qiuling Du, Chunguang Yang, Haiming Jiang, Yanmei Hu, Ping Sun, Jianghong Dong, Wei Cui, Kefeng Wang, Jun Wang, Yaoquan Tu, Zifeng Yang, Wenhui Hu *. Discovery of Highly Potent Pinanamine-Based Inhibitors Against Amantadine- and Oseltamivir-resistant Influenza A Viruses. Journal of Medicinal Chemistry. 2018, 61, 5187−5198.

2. Hui Xie, Shaogao Zeng, Yuwen He, Guicheng Zhang, Pengjiu Yu, Guifa Zhong, Hongjiang Xu, Ling Yang, Shanchun Wang, Xin Zhao*, Wenhui Hu*. Rapid generation of a novel DPP-4 inhibitor with long-acting properties: SAR study and PK/PD evaluation. European Journal of Medicinal Chemistry, 2017, 141, 519-529.

3. Yunlong Zhao, Qingxin Zhao, LS Wang, Wen Hui Hu*, Jun Ling Zhao*. Organocatalytic Friedel-Crafts Alkylation /Lactonization Reaction of Naphthols with 3-Trifluoroethylidene Oxindoles: The Asymmetric Synthesis of Dihydrocoumarins. Angewandte Chemie International Edition. 2017, 56, 338 –342.

4. Runfeng Li, Chunguang Yang, Qiuling Du, Xin Zhao, Haiming Jiang, Wenhui Hu*, Zifeng Yang*. Pinanamine Is a Promising Lead Compound against Influenza A Virus: Evidence from in Vitro and in Vivo Efficacy Compared to Amantadine. Biological & pharmaceutical bulletin. 2017, 40, 954–959.

5. Wei Zhou, Guifa Zhong, Sihai Fu, Hui Xie, Tianyan Chi, Luyi Li, Xiurong Rao，Shaogao Zeng, Dengfeng Xu, Hao Wang, Guoqing Sheng, Xing Ji, Xiaorong Liu, Xuefei Ji, Donghai Wu, Libo Zou, Micky Tortorella, Kejian Zhang, and Wenhui Hu*. Microglia-based phenotypic screening identifies a novel inhibitor of neuroinflammation effective in Alzheimer's Disease Models. ACS Chemical Neuroscience. 2016, Nov 16;7 (11):1499-1507.

6. Jianghong Dong, Shengwei Chen, Runfeng Li, Wei Cui, Haiming Jiang, Yixia Ling, Zifeng Yang, Wenhui Hu*. Imidazole-based pinanamine derivatives: Discovery of dual inhibitors of the wild-type and drug-resistant mutant of the influenza A virus. European Journal of Medicinal Chemistry. 2016, 108, 605-615.

7. Shengwei Chen, Qinxin Lou, Yuyang Ding, Shasha Zhang, Wenhui Hu* and Junling Zhao* Organocatalytic enantioselective Michael reaction of malononitrile to b,b-disubstituted nitroalkenes. Advanced Synthesis & Catalysis. 2015, 357, 2437-2441.

8. Shengwei Chen, Guicheng Zhang, Qxinxin Lou, Wei Cui, Shasha Zhang, Wenhui Hu* and Junling Zhao*. Organocatalytic enantioselective aza-Michael reaction of benzotriazole to β,β-disubstituted nitroalkenes. ChemCatChem. 2015, 7, 1935-1938.

9. Yuyang Ding, Liufeng Mao, Dengfeng Xu, Hui Xie, Ling Yang, Hongjiang Xu, Wenjun Geng, Yong Gao, Chunguang Xia, Xiquan Zhang, Qingyi Meng, Donghai Wu, Junling Zhao * and Wenhui Hu*. C-aryl glucoside SGLT2 inhibitors containing a biphenyl motif as potential anti-diabetic agents. Bioorganic & Medinal Chemistry letter. 2015, 25, 2744-2748.

10. Bo Bi, Qin-Xin Lou, Yu-Yang Ding, Sheng-Wei Chen, Sha-Sha Zhang, Wen-Hui Hu* and Jun-Ling Zhao* Chiral phosphoric acid-catalyzed highly enantioselective Friedel-Crafts alkylation reaction of C3-substituted indoles to unsaturated ketimino esters. Organic Letters, 2015, 17, 540−543.