陈文杰，男，2020年作为南山学者骨干人才特聘教授加入药学院，专业方向是分子药剂学。2011年本科毕业于中国药科大学药学院；2014年硕士毕业于中国农业科学院纳米农业研究中心；2018年博士毕业于澳大利亚麦考瑞大学/新南威尔斯大学纳米生物光子学中心，随后在美国明尼苏达大学、弗吉尼亚联邦大学博后工作两年。主要研究方向是用于基因/药物转送载体，可控的基因/药物传输纳米材料用于基因/免疫治疗、肿瘤协同治疗、光动力治疗。近期在研纳米脂质材料递送siRNA/CRISPR 编辑的癌症免疫疗法， DNA/mRNA核酸疫苗，靶向多肽化疗药物。主要学术业绩有：以第一作者在Molecular therapy 等权威杂志发表SCI文章8篇，其中JCR1区5篇；英文专著一章；专业领域多种SCI期刊审稿人，Chinese Chemical Letters优秀审稿人。

【联系邮箱】

Wjchen@gzhmu.edu.cn

【研究方向】

分子药剂学，药物递送，核酸药物，免疫治疗，基因编辑等

【主要科研项目】

广州市高水平建设大学项目，2021-2025，200万

【所获荣誉和奖励】

VCU药学院最佳墙报奖；麦考瑞大学国际生优秀研究奖学金(iMQRES)；麦考瑞大学博士研究生研究基金(PGRF); 悉尼癌症转化研究计划Sydney Vital fellowship on Flag Nanotechnology提名。中国农业科学院研究生院优秀奖学金，研究生院党总支优秀党员干部；中国药科大学学业优秀奖学金若干次，社会实践优秀个人，优秀共青团员干部。

【主要论文及著作（代表性）】

期刊文章(Selected publication)：

1. *Chen W, *Deng W, & Goldys EM (2020) Light-induced liposomes for cancer therapeutics. Progress in Lipid Research. Online, https://doi.org/10.1016/j.plipres.2020.101052. IF=15.1

2. Zhou S, Chen W, Cole J, & Zhu G. (2020). Delivery of nucleic acid therapeutics for cancer immunotherapy. Medicine in Drug Discovery, 100023. In Press.

3. Aksoy YA, Chen W, *Goldys EM, & *Deng, W. (2020). Spatial and temporal control of CRISPR/Cas9-mediated gene editing delivered via a light-triggered liposome system. ACS Applied Materials & Interfaces, accepted.

4. Deng W, Chen W, Clement S, Guller A, Zhao Z, Eagle A, *Goldys EM (2018). X-ray triggered liposomal delivery system for gene knockdown and chemotherapy, Nature Communication, 9 (1), 2713. IF=12.1.

5. Chen W, Zhao X, Deng W, Vo J, Goldys EM, *Cui H(2018). Magnetically and photochemically triggered nanomaterial platforms for non-viral DNA delivery. Journal of Gene Medicine 20 (1). IF=3.2.

6. Chen W, *Deng W, & *Goldys EM (2017). Light-triggerable liposomes for enhanced endolysosomal escape and gene silencing in PC12 cells. Molecular Therapy-Nucleic Acids, 7, 366-377. IF=6.3

7. ^#Clement S, ^#Chen W, Deng W, Goldys EM (2018). Folic acid conjugated biodegradable nanoparticle – photosensitizer matrix for targeted deep tumour therapy, ^#co-first authors, International Journal of Nanomedicine, 13, 3553. IF=5.1。^#共同一作。

8. Clement S, Chen W, Anwer AG, & Goldys EM (2017). Verteprofin conjugated to gold nanoparticles for fluorescent cellular bioimaging and X-ray mediated photodynamic therapy. Microchimica Acta, 184(6), 1765-1771. IF=6.2

9. Chen W, Deng W, Vo J, *Goldys EM (2017). Enhanced plasmid DNA delivery from photo-triggered stealth liposomes. Molecular Therapy, 25 (5), 220. IF=8.9

10. Chen W, *Deng W, Xu X, Zhao X, Vo JN, Anwer AG, Williams TC, Cui H, *Goldys EM (2018). Photoresponsive endosomal escape enhances gene delivery using liposome–polycation–DNA (LPD) nanovectors. Journal of Materials Chemistry B, 6, 5269-5281. IF=5.3

11. ^#Zhao X, ^#Meng Z, ^#Wang Y, Chen W, Sun, C, Cui, B, Yu M, Zeng Z, Guo S, Luo D, Cheng JQ, Zhang R, *Cui H (2017). Pollen magnetofection for genetic modification with magnetic nanoparticles as gene carriers. Nature Plants 3, 956–964. #co-first authors. IF=13.3

12. Chen W, Deng W, Vo J, *Goldys EM. Photochemically activated liposomal platform for enhanced nuclei acids delivery. Human Gene Therapy (Vol. 28, No. 12, pp. A122-A123). IF=4.3

13. Chen W, *Cui H, Zhao X, Cui J, Wang Y, Sun C, & Lei F (2015). Characterization and insights into the nano liposomal magnetic gene vector used for cell co-transfection. Journal of Nanoscience and Nanotechnology, 15(8), 5530-5536. IF=1.1

14. Chen W, Cui H, Zhao X, Cui J, Wang Y, Sun C, & Lei F (2015). Construction and characterization of liposomal magnetofection system in pig kidney cells. Chin J Biotech, 2014, 30(6): 972−981.

    会议

    1. Chen W, Deng W, Goldys EM. Light enhances endosomal escape and DNA delivery. Oral, 2017 International Conference on BioNano Innovation 24-27 September 2017, Brisbane.

    2. Chen W, Deng W & Goldys EM. Enhanced gene silencing mediated by photoresponsive liposomes. Deng W, Goldys EM. Enhanced gene silencing mediated by photoresponsive liposomes. Poster. SPIE BioPhotonics Australasia, 17-19 Oct 2016, Adelaide. DOI: 10.1117/12.2244465.

    3. Chen W, Zhao X, Cui J, Cui H, Wang Y & Goldys EM. Characterization and Cell Con-Transfection Using Liposomal Magnetic Nanoparticles. 6^th International Nanomedicine Conference. 6 - 8 July 2015, Sydney.

    Book chapters:

    专业著作

    1. Chen W, Deng W, Goldys EM. Recent developments of light - triggered liposome nanosystems for cancer treatments. Accepted, Jan 2020 已接收待发表. Functional lipid nanosystems in cancer - Pan Stanford Publishing. Invited book chapter.