【个人简介（短文形式）】

刘夏雯，女，副教授。主要研究方向为新药研发中的药物代谢及小分子代谢调控研究。2007年-2013年，师从袁牧教授，在广州医科大学药物研发中心从事新药药物代谢研究工作，于2013年获得博士学位。同年留任药物研发中心，研究方向拓展为小分子代谢调控研究，主要研究药物对代谢酶的调控机制及雄激素代谢调控在雄激素蓄积疾病中的作用机制及化学干预研究。作为项目负责人获得国家自然科学基金和广东省自然科学基金各一项立项，作为主要参与者参加多项国家级省级课题。2022.10-2023.10由国家公派项目资助，在新加坡国立大学Matthew Kemp教授实验室进行访问学习。

【联系邮箱】

lxwgzhmu@gzhmu.edu.cn

【研究方向】  

1. 新药开发中药物的体内外药代动力学研究；

2. 小分子与代谢酶的相互作用机制研究。

【主要科研项目】

1. 主持2022年广东省自然科学基金青年提升项目，FXR-UGT2B15-DHT-AR轴调控PCOS的生物学机制及其化学干预治疗作用（项目批准编号：2023A1515030041），在研，30万，2023.01-2025.12

2. 主持2020年广州市教育局青年人才科研项目，Naftopidil及代谢物通过FXR-UGT2B15抑制雄激素蓄积发挥抗前列腺癌的机制研究（项目批准编号：202032813），结题，5万，2021.01-2022.12

3. 主持2016年国家自然科学基金青年项目，从Naftopidil对映体诱导雄激素代谢探讨抗良性前列腺增生新靶点（项目批准号：81503131），结题，20万，2016.01-2018.12

4. 主持2014年广州市属高校科研项目，手性药物naftopidil影响雄激素代谢与预防前列腺癌作用的相关性（立项编号：1201430376），5万，2015.03-2017.03

【主要论文及著作（代表性）】

1. Silin Zhang^#, Haiman Zhang^#, Xiawen Liu^#, Ping Qi, Tingting Tan, Shengdong Wang, Hui Gao, Hongtao Xu, Zhi Zhou, and Wei Yi*, Mask and release strategy-enabled diversity-oriented synthesis for DNA-encoded library. Advanced Science, 2023, 2307049.

2. Haoxin Zhan^#, Silin Zhang^#, Lirong Li, Zikai Chen, Yi Cai, Junjun Huang, Dan Wu, Biyun Huang, Bo Wu*, Xiawen Liu*, Naftopidil enantiomers suppress androgen accumulation and induce cell apoptosis via the UDP-glucuronosyltransferase 2B15 in benign prostate hyperplasia. Journal of Steroid Biochemistry and Molecular Biology, 2022, 221: 106117.

3. Lei Ma, Junyuan Tang, Guihui Cai, Fangyuan Chen, Qingmei Liu, Zhi Zhou, Silin Zhang, Xiawen Liu*, Ning Hou*, Wei Yi*, Structure-based screening and biological validation of the anti-thrombotic drug-dicoumarol as a novel and potent PPARγ-modulating ligand. Bioorganic Chemistry, 2022, 129, 106191.

4. Xiawen Liu, Yi Rong, Xingfei Zhang, Junjun Huang, Yi Cai, Biyun Huang, Liu Zhu, Bo Wu, Ning Hou, Chengfeng Luo. Human UDP-Glucuronosyltransferase 2B4 and 2B7 are responsible for naftopidil glucuronidation in Vitro. Frontiers in Pharmacology. 2018, 8, 984.

5. Xiawen Liu, Lijun Zhu, Biyun Huang, Junjun Huang, Yi Cai, Liu Zhu, Bo Wu, Xiaojing Fu, Xingfei Zhang, Yi Rong, Qing Xiao, Jiewen Guo, Arong Li, Yifei Guo, Mu Yuan. Poor and enantioselective bioavailability of naftopidil enantiomers is due to extensive and stereoselective metabolism in rat liver. Journal of Pharmaceutical and Biomedical Analysis. 2017, 132, pp 165-172.

6. Yi Rong, Biyun Huang, Junjun Huang, Liu Zhu, Xiawen Liu*. A rapid and simple ultraperformance liquid chromatography coupled to tandem mass spectrometry (UPLC-MS/MS) method for the detection of glucuronic acid-conjugated steroid metabolites. Journal of Chinese Pharmaceutical Sciences. 2016, 25(4), pp 291-301.

7. Xiawen Liu, Xingfei Zhang, Junjun Huang, Yi Rong, Chengfeng Luo, Jiewen Guo, Liu Zhu, Biyun Huang, Mu Yuan*. Enantiospecific determination of naftopidil by RRLC-MS/MS reveals stereoselective pharmacokinetics and tissue distributions in rats. Journal of Pharmaceutical and Biomedical Analysis. 2015, 112: 147-154.

8. Lijun Zhu^#, Xiawen Liu^#, Liu Zhu, Xingfei Zhang, Xiaojing Fu, J unjun Huang, Mu Yuan*. Identification of human cytochrome P450 isozymes involved in the metabolism of naftopidil enantiomers in vitro. Journal of Pharmacy and Pharmacology. 2014, 66(11):1534-1551

9. Yunying Zhang^#, Xiawen Liu^#, Mu Yuan*, Lijun Zhu. Simultaneous stereoselective analysis of naftopidil and O-desmethyl naftopidil enantiomers in rat feces using an online column-switching high performance liquid chromatography method. Journal of Biomedical Chromatography. 2014, 28:1030-1035

10. Xiawen Liu, Yunying Zhang, Mu Yuan*, Yinxiang Sun. Determination of Naftopidil enantiomers in rat plasma using chiral solid phases and pre-column derivatization high performance Liquid Chromatography. Journal of Chromatography B. 2012 (907) 140-145.