王玉青，女，博士，广州医科大学药学院药物化学教研室副教授。2013获中山大学药学专业学士学位，2018获中山大学药物化学博士学位。2018年7月入职广州医科大学药学院，工作至今。目前已在国内外重要刊物上发表SCI论文十余篇，申请专利多项。主持国家自然科学基金1项、广东省教育厅项目基金1项、广州市科技厅项目1项、广州医科大学大学生实验室开放项目1项、参与多项国家级和省级项目。参与本科教学课程《有机化学》、《药物化学》、《波谱解析》、《新药研究与开发应用》。

【联系邮箱】gzhmu-wyq@foxmail.com

【研究方向】 （1）抗肿瘤小分子化合物的设计、合成、活性评价和作用机制研究；（2）以核酸和相关蛋白质为靶点的药物化学与化学生物学研究

【主要科研项目】

1. 国家自然科学基金青年基金项目，81903467，基于癌基因c-myc转录调控的新型抗耐药非小细胞肺癌的先导化合物发现及作用机制研究。2020/01-2022/12，20万元，在研，主持。

2. 广州市科技计划项目，202002030410，新型喹唑啉类 c-myc 转录抑制剂合成、构效关系及抗耐药肺癌研究，2020/04-2023/03，20万元，在研，主持。

3. 广东省教育厅项目，2020KTSCX103，靶向c-myc转录的骆驼藤碱类衍生物的设计、合成及抗非小细胞肺癌活性研究，2021/01-2022/12，5万元，在研，主持。

4. 广州医科大学2020年大学生实验室开放项目，PX-1020418，骆驼藤碱类c-myc启动子G-四链体选择性配体的设计合成及活性研究，2020/01-2021/12，2万元，在研，主持。

【主要论文及著作（代表性）】

(1).Yu-Qing Wang, Zhou-Li Huang, Shuo-Bin Chen, Chen-Xi Wang, Chan. Shan, Qing-Kun Yin, Tian-Miao Ou, Ding Li, Lian-Quan Gu, Jia-Heng Tan* and Zhi-Shu Huang*. Design, Synthesis, and Evaluation of New Selective NM23-H2 Binders as c-MYC Transcription Inhibitors via Disruption of the NM23-H2/G-quadru plex Interaction. Journal of Medicinal Chemistry, 2017, 60(16), 6924−6941.

(2).Yu-Qing Wang^#, Ming-Hao Hu^#, Rui-Jun Guo, Shuo-Bin Chen*, Zhi-Shu Huang and Jia-Heng Tan*. Tuning the Selectivity of a Commercial Cyanine Nucleic Acid Dye for Preferential Sensing of Hybrid Telomeric G-Quadruplex DNA. Sensors & Actuators: B. Chemical. 2018, 266, 187-194.

(3).Yu-Qing Wang, Meng-Ying Ji, Chang Wang*. Endoplasmic Reticulum- Targeted Glutathione and pH Dual Responsive Vitamin Lipid Nanovesicles for Tocopheryl DM1 Delivery and Cancer Therapy. International Journal of Pharmaceutics 2020, 582, 119331

(4).Ming-Hao Hu^#, Yu-Qing Wang^#, Ze-Yi Yu, Lu-Ni Hu, Tian-Miao Ou, Shuo-Bin Chen*, Zhi-Shu Huang and Jia-Heng Tan*. Discovery of a New Four-Leaf Clover-Like Ligand as a Potent c-MYC Transcription Inhibitor Specifically Targeting the Promoter G-Quadruplex. Journal of Medicinal Chemistry, 2018, 61(6), 2247−2459.

(5). Zhong-Nan Xu^#, Yu-Qing Wang^#, Yu-Cheng Zheng, Zhi-Xing Huang, Lutz Ackermann and Zhi-Xiong Ruan*. Manganese- and rhenium-catalyzed C–H enaminylation: expedient access to novel indolepurine hybrids with anti-tumor bioactivities. Organic Chemistry Frontiers, 2020,7:3709-3714.

(6). Chao-Yue Su^#, Hui Wang^#, Yan-Rui Pan^#, Ling-Ling Zhang, Qiao-Ru Guo, Yan-Yan Yan, Jia-Jun Li, Jia-Li Fu, Xin-Yue Fan, Yu-Qing Wang*, Jian-Ye Zhang*. Dehydrocostus lactone exerts the antitumor effect in non-small cell lung cancer H1299 cells. TMR Cancer, 2020, 3(3): 101-111.

(7).Tong Che, Yu-Qing Wang, Zhou-Li Huang, Jia-Heng Tan, Zhi-Shu Huang and Shuo-Bin Chen*. Natural Alkaloids and Heterocycles as G-Quadruplex Ligands and Potential Anticancer Agents. Molecules, 2018, 23, 493.

(8).Qi-Kun Yin, Chen-Xi Wang, Yu-Qing Wang, Shuo-Bin Chen*, and Zhi-Shu Huang* etc. Discovery of Isaindigotone Derivatives as Novel Bloom’s Syndrome Protein (BLM) Helicase Inhibitors That Disrupt the BLM/DNA Interactions and Regulate the Homologous Recombination Repair. Journal of Medicinal Chemistry, 2019, 62 (6), 3147–3162

(9).Chan Shan^#, Jin-Wu Yan^#, Yu-Qing Wang, Tong Che, Zhou-Li Huang, Ai-Chun Chen, Pei-Fen Yao, Jia-Heng Tan, Ding Li, Tian-Miao Ou*, Lian-Quan Gu and Zhi-Shu Huang*. Design, Synthesis and Evaluation of Isaindigotone Derivatives to Downregulate c-myc Transcription via Disrupting the Interaction of NM23-H2 with G-Quadruplex. Journal of Medicinal Chemistry, 2017, 60 (4), 1292–1308.

(10). Ming-Hao Hu, Shuo-Bin Chen, Yu-QingWang, You-Mei Zeng, Tian-Miao Ou, Ding Li, Lian-Quan Gu Zhi-Shu Huang and Jia-Heng Tan*. Accurate High-throughput Identification of Parallel G-quadruplex Topology by a New Tetraaryl-substituted Imidazole. Biosensors and Bioelectronics, 2016, 83, 77-84.

(11). Tong Che, Shuo-Bin Chen, Jia-Li Tu, Bo Wang, Yu-Qing Wang, Yan Zhang, Jing Wang, Zeng-Qing Wang, Ze-Peng Zhang, Tian-Miao Ou, Yong Zhao, Jia-Heng Tan* and Zhi-Shu Huang*. Discovery of Novel Schizocommunin Derivatives as Telomeric G-Quadruplex Ligands That Trigger Telomere Dysfunction and the Deoxyribonucleic Acid (DNA) Damage Response Journal of Medicinal Chemistry .2018, 61(8), 3436-3453