个人简介：

    邵攀霖，理学博士，教授，硕士研究生/博士研究生导师。2006年于四川师范大学取得学士学位（导师：赵可清教授），2011年于中国科学院化学研究所取得博士学位（导师：叶松研究员），2012年~2014年于新加坡国立大学从事博士后研究工作（导师：赵宇教授）。长期致力于生物活性分子及药物的不对称合成研究，发展了一系列新颖、独特且高效的不对称催化体系，并将其应用于新药研发以及重大手性药物产业化的关键技术研究。在国内外著名高校与研究机构主持和参与了多个科研项目，研究成果在J. Am. Chem. Soc.，Angew. Chem., Int. Ed.，ACS Catalysis等学术期刊发表40余篇；授权发明专利11项。作为负责人和主要参与人，利用关键的平台性技术，开展了数十项大品种原料药的合成工艺开发，包括以多肽药物为导向的系列氨基酸的合成，以及以手性药物为导向的系列小分子原料药的合成。

研究方向：药物化学、体外诊断

主要着眼于基于胸腔慢病的手性药物和生物功能材料的开发，具体包括两个研究方向：（1）不对称催化体系的开发并将其应用于手性药物的绿色合成；（2）新型有机小分子荧光“探针”的开发并将其应用于体外诊断。

代表性论文：

(1) Jingkai Yang^#, Ziyi Xu^#, Le Yu, Bingyun Wang, Ruibin Hu, Jiahu Tang, Jiahui Lv, Hongjun Xiao, Xuan Tan, Guanghui Wang, Jia-Xin Li, Ying Liu*, Pan-Lin Shao*, Bo Zhang*, Organic Fluorophores with Large Stokes Shift for the Visualization of Rapid Protein and Nucleic Acid Assays, Angewandte Chemie-International Edition, 2024, e202318800.

(2) Jiang Wang, Pan-Lin Shao*, Xin Lin, Baode Ma, Jialin Wen, Xumu Zhang*, Facile Synthesis of Enantiopure Sugar Alcohols: Asymmetric Hydrogenation and Dynamic Kinetic Resolution Combined, Angewandte Chemie-International Edition, 2020, 59, 18166-18171.

(3) Pan-Lin Shao, Jia-Yu Liao, Yee Ann Ho, Yu Zhao*, Highly Diastereo- and Enantio-selective Ag-Catalyzed Double [3+2] Cyclization of a-Imino Esters with Isocyanoacetate, Angewandte Chemie-International Edition, 2014, 53, 5435-5439.

(4) Pan-Lin Shao, Xiang-Yu Chen, Song Ye*, Formal [3+2] Cycloaddition of Ketenes and Oxaziridines Catalyzed by Chiral Lewis Bases: Enantioselective Synthesis of Oxazolin-4-ones, Angewandte Chemie-International Edition, 2010, 49, 8412-8416.

(5) Jia-Yu Liao,^# Pan-Lin Shao^# (co-first author), Yu Zhao*, Catalytic Divergent Synthesis of 3H or 1H Pyrroles by [3+2] Cyclization of Allenoates with Activated Isocyanides, Journal of the American Chemical Society, 2015, 137, 628-631.

(6) Jiahu Tang ^#, Ruibin Hu^#, Yiyi Liu, Jingchao Liu, Guanghui Wang, Jiahui Lv, Li Cheng, Tingzhen He, Ying Liu*, Pan-Lin Shao*, Bo Zhang*, Deciphering ACE2-RBD Binding Affinity through Peptide Scanning: A Molecular Dynamics Simulation Approach, Computers in Biology and Medicine, 2024, Doi: https://doi.org/10.1016/ j.compbiomed.2024.108325.

(7) Zijuan Yan^#, Pan-Lin Shao^#,*, Qing Qiang^#, Feipeng Liu*, Xuchao Wang, Yongjie Li, Zi-Qiang Rong*, Transition metal-catalyzed conversion of aldehydes to ketones via direct C-H bond functionalization, Chinese Chemical Letters, 2022, 33, 1207-1226.

(8) Jiang Wang, Xin Lin, Pan-Lin Shao*, Jingyuan Song, Jialin Wen, Xumu Zhang*, Double Asymmetric Hydrogenation of α-iminoketones: Facile Synthesis of Enantiopure Vicinal Amino Alcohols, ACS Catalysis, 2021, 11, 12729-12735.

(9) Kun-Quan Chen,^# He Sheng,^# Qiang Liu, Pan-Lin Shao*, Xiang-Yu Chen*, N-Heterocyclic Carbene-Catalyzed Radical Reactions, Science China-Chemistry, 2021, 64, 7-16.

(10) Tiao-Zhen Zhu, Pan-Lin Shao*, Xumu Zhang*, Asymmetric Hydrogenation of Trifluoromethyl Ketones: Application in the Synthesis of Odanacatib and LX-1031, Organic Chemistry Frontiers, 2021, 8, 3705-3711.

(11) Zhi-Peng Wang, Qi Wu, Jia Jiang, Zi-Rui Li, Xiao-Jiao Peng, Pan-Lin Shao*, Yun He*, Catalytic Asymmetric Synthesis of Pyrrolidine Derivatives Bearing Heteroatom-Substituted Quaternary Stereocenters, Organic Chemistry Frontiers, 2018, 5, 36-40.

(12) Xiao-Jiao Peng,^# Yee Ann Ho,^# Zhi-Peng Wang, Pan-Lin Shao*, Yu Zhao*, Yun He*, Formal [3+2] Cycloaddition of a-Unsubstituted Isocyanoacetates and Methyleneindolinones: Enantioselective Synthesis of Spirooxindoles, Organic Chemistry Frontiers, 2017, 4, 81-85.

(13) Zhong-Lin Zang,^# Shuklachary Karnakanti,^# Sheng Zhao, Ping Hu, Zhen Wang, Pan-Lin Shao*, Yun He*, Synthesis of Spiro-Dihydroquinoline and Octahydrophenanthrene Derivatives via Palladium-Catalyzed Intramolecular Oxidative Arylation, Organic Letters, 2017, 19, 1354-1357.

(14) Zhong-Lin Zang,^# Sheng Zhao,^# Shuklachary Karnakanti, Cheng-Lin Liu, Pan-Lin Shao*, Yun He*, Catalytic Multisite-Selective Acetoxylation Reactions at sp² vs sp³ C−H Bonds in Cyclic Olefins, Organic Letters, 2016, 18, 5014-5017.

(15) Panlin Shao, Li-Tao Shen, Song Ye*, Asymmetric Synthesis of Terminal 1,2-Diols from Acyl Chlorides, Chinese Journal of Chemistry, 2012, 30, 2688-2692.

授权专利：

（1）邵攀霖，马保德，王江，丁小兵，张绪穆，合成氢硫酸氯吡格雷及其中间体的新方法，专利号：ZL201910044148.8

（2）马保德，邵攀霖，吴超，王江，张绪穆，ɑ-羟基酸制备方法，专利号：ZL201910044633.5

（3）谭雪锋，晏邵佰，邵攀霖，张绪穆，钌-双膦催化剂催化的简单酮的不对称还原胺化制备手性伯胺，专利号：ZL201910092496.2

（4）朱绪成，邹毅，邵攀霖，贺耘，制备4-[4-({[4-氯-3-(三氟甲基)苯基]氨基甲酰}氨基)-3-氟苯氧基]-N-甲基吡啶-2-甲酰胺及其一水合物的方法，专利号：ZL201510035485.2

（5）周兴华，王志鹏，彭小娇，郑绍军，邵攀霖，贺耘，三嗪衍生物的不对称合成方法，专利号：ZL201510154682.6

（6）王志鹏，向四川，邵攀霖，贺耘，一种具有螺环结构的吡咯啉衍生物的不对称合成方法，专利号：ZL201810735998.8

（7）邵攀霖，王志鹏，胡平，贺耘，一种杂原子取代的吡咯烷衍生物的不对称合成方法，专利号：ZL201710201866.2

（8）王志鹏，邵攀霖，贺耘，一种氢氧化钠催化的多取代吡咯合成新方法，专利号：ZL201810735987.X

（9）马保德，邵攀霖，吴超，王江，张绪穆，一种羟基酰胺的制备方法，专利号：ZL201910900851.4

（10）高爽，丁小兵，邵攀霖，一种串联还原胺化合成手性内酰胺的方法，专利号：ZL201910715880.3

（11）马保德，邵攀霖，吴超，王江，张绪穆，一种羟基内酰胺的制备方法，专利号：ZL201910901614.X