【个人简介】

徐有伟，男，南山学者第四层次，2011年硕士毕业于复旦大学，师从徐彦辉教授；2017年博士毕业于德国慕尼黑大学，师从德国科学院院士、美国科学院外籍院士、马普学会主席Patrick Cramer教授；2017年至2025年，先后在上海科技大学（Ian Wilson教授）、中国科学院上海药物研究所（徐华强教授）任助理研究员、副研究员。2025年3月加入广州医科大学药学院。

目前已发表文章近40篇，其中一作，并列一作，以及并列通讯的文章有16篇，包括Science，Cell Research，Nature Communications，Science Advances，Nature Structural & Molecular Biology以及PNAS等。主持过国家自然科学基金青年项目。

【联系邮箱】

2025991004@gzhmu.edu.cn

【研究方向类别】

学术学位：药物化学

【具体研究方向】

基于重大疾病相关的蛋白质三维结构的药物开发研究与精准药物设计。聚焦于通过冷冻电镜（Cryo-EM）、X射线晶体学及人工智能驱动的分子动力学模拟技术，解析癌症、神经退行性疾病及代谢性疾病中关键靶标蛋白（如核受体、突变型激酶、GPCR及离子通道）的动态构象与变构调控机制，结合高通量虚拟筛选与自由能微扰计算，针对正构/变构结合位点设计高选择性小分子抑制剂或激动剂，并利用单细胞测序验证药物效价与通路特异性，同时构建多尺度结构-功能数据库以优化药物，最终实现从原子精度解析致病蛋白互作网络到临床前候选药物开发的转化闭环。

【主要科研项目】

国家自然科学基金青年项目（已结题）

【所获荣誉和奖励】

2017年度国家优秀自费留学生奖学金

2024年度赛诺菲优秀青年人才奖

【主要论文及著作（代表性）】

1. Youwei Xu #, Canrong Wu #, Xiaodan Cao #, Chunyin Gu #, Heng Liu #, Mengting Jiang, Xiaoxi Wang,

Qingning Yuan, Kai Wu, Jia Liu, Deyi Wang, Xianqing He, Xueping Wang, Su-Jun Deng *, H Eric Xu *, and Wanchao Yin * (2022). Structural and biochemical mechanism for increased infectivity and immune evasion of Omicron BA.2 variant compared to BA.1 and their possible mouse origins. Cell Res 32, 609-620, doi:10.1038/s41422-022-00672-4 (2022). 影响因子：46.297

2. Youwei Xu #, *, Hongmin Cai #, Chongzhao You, Xinheng He, Qingning Yuan, Hualiang Jiang, Xi Cheng, Yi Jiang, and H Eric Xu * (2022). Structural insights into ligand binding and activation of the human thyrotropin-releasing hormone receptor. Cell Res, doi:10.1038/s41422-022-00641-x (2022). 影响因子：46.297；第一, 并列通讯 _

3. Youwei Xu, Carrie Bernecky, Chung-Tien Lee, Kerstin C Maier, Björn Schwalb, Dimitry Tegunov, Jürgen M Plitzko, Henning Urlaub, and Patrick Cramer * (2017). Architecture of the RNA polymerase II-Paf1C-TFIIS transcription elongation complex. Nat Commun 8: 15741, doi:10.1038/ncomms15741 (2017). 影响因子：14.919

4. Wanchao Yin #, *, Youwei Xu #, Peiyu Xu #, Xiaodan Cao #, Canrong Wu #, Chunyin Gu #, Xinheng He, Xiaoxi Wang, Sijie Huang, Qingning Yuan, Kai Wu, Wen Hu, Zifu Huang, Jia Liu, Zongda Wang, Fangfang Jia, Kaiwen Xia, Peipei Liu, Xueping Wang, Bin Song, Jie Zheng, Hualiang Jiang, Xi Cheng, Yi Jiang, Su-Jun Deng *, and H Eric Xu * (2022). Structures of the Omicron spike trimer with ACE2 and an anti-Omicron antibody. Science 375, 1048-1053, doi:10.1126/science.abn8863 (2022). 影响因子：63.714；并列第一 _

5. Canrong Wu #*, Youwei Xu #, Qian He, Dianrong Li, Jia Duan, Changyao Li, Chongzhao You, Han Chen, Weiliang Fan, Yi Jiang, and H Eric Xu * (2023). Ligand-induced activation and G protein coupling of prostaglandin F2α receptor. Nat Commun 14, 2668, doi: 10.1038/s41467-023-38411-x (2023). 影响因子：17.694; 并列第一 _

6. Hongmin Cai #, Shimeng Guo#, Youwei Xu#, Zhikan Xia#, Junrui Li, Jun Sun, Yi Jiang, Xin Xie*, and H. Eric Xu*. Cryo-EM structures of adenosine receptor A3AR bound to selective agonists. Nat Commun 15, 3252, doi: 10.1038/s41467-024-47207-6 (2024) 影响因子：17.694; 并列第一 _

7. Chongzhao You#, Yumu Zhang#, Youwei Xu#, Peiyu Xu, Zhen Li, Huadong Li, Sijie Huang ,Zecai Chen, Jingru Li, H. Eric Xu*, and Yi Jiang* (2023). Structural basis for motilin and erythromycin recognition by motilin receptor. Sci Adv, doi: 10.1126/sciadv.ade9020 (2023). 影响因子：14.98；并列第一 _

8. Changyao Li#, Youwei Xu#, Heng Liu#, Hongmin Cai, Yi Jiang, H Eric Xu*, and Wangchao Yin*. (2022). Molecular recognition of itch-associated neuropeptides by bombesin receptors. Cell Res, doi:10.1038/s41422-022-00743-6 (2022). 影响因子：46.297；并列第一 _

9. Hongmin Cai#, Youwei Xu#, Shimeng Guo#, Xinheng He, Jun Sun, Xin Li, Changyao Li, Wanchao Yin, Xi Cheng, Hualiang Jiang, H. Eric Xu*, Xin Xie*, and Yi Jiang* (2022). Structures of adenosine receptor A2BR bound to endogenous and synthetic agonists. Cell Discov, doi: 1038/s41421-022-00503-1. 影响因子：38.079；并列第一 _

10. Jun Niu#, Qi Wang#, Wenwen Zhao#, Bing Meng#, Youwei Xu#, Xianfang Zhang, Yi Feng, Qilian Qi, Yanling Hao, Xuan Zhang, Ying Liu, Jiangchao Xiang, Yiming Shao *, and Bei Yang *. (2023). Structures and immune recognition of Env trimers from two Asia prevalent HIV-1 CRFs. Nat Commun 14, 4676, doi: 10.1038/s41467-023-40321-x (2023). 影响因子：17.694 ; 并列第一 _

11. Qianmin Wang #, Shaobai Li #, Futang Wan #, Youwei Xu #, Zhenfang Wu, Mi Cao, Pengfei Lan *, Ming

Lei *, Jian Wu * (2021). Structural insights into transcriptional regulation of human RNA polymerase III. Nat Struct Mol Biol 28(2): 220-227, doi:10.1038/s41594-021-00557-x (2021). 影响因子：15.369；并列第一 _

12. Qianmin Wang #, Julia L. Daiss #, Youwei Xu*, Christoph Engel* (2022). Snapshots of RNA polymerase III in action - A mini review (2022). Gene 821, 146282, doi: 10.1016/j.gene.2022.146282 (2022). 影响因子：3.913; 并列通讯；受邀综述 _

13. Wenjia Fan #, Youwei Xu #, Xinheng He #, Ping Luo, Jingpeng Zhu, Junrui Li, Ruolan Wang, Qingning Yuan, Kai Wu, Wen Hu, Yuxi Zhao, Shiqi Xu, Xi Cheng, Yue Wang*, H Eric Xu*, and Youwen Zhuang*. Structure basis of the human platelet-activating factor receptor PAFR recognized by the endogenous phospholipid PAF. Cell Reports (2024). DOI: https://doi.org/10.1016/j.celrep.2024.114422. 影响因子：8.8；并列第一 _

14. Changyao Li #, Youwei Xu #, Wenxin Su, Xinheng He, Jingru Li, Xinzhu Li, H.Eric Xu*, and Wanchao Yin*. Structural insights into ligand recognition, selectivity, and activation of bombesin receptor subtype-3. Cell Reports (2024). DOI:https://doi.org/10.1016/j.celrep.2024.114511. 影响因子：8.8；并列第一 _

15. Sanshan Jin #, Xin Li #, Youwei Xu #, Shimeng Guo #, Canrong Wu #, Benxun Pan, Wenwen Xin, Heng Zhang, Wen Hu , Yuling Yin, Tianwei Zhang, Kai Wu, Qingning Yuan, H. Eric Xu*, Xin Xie*, and Yi Jiang*. Structure basis for recognition of 26RFa by the pyroglutamylated RFamide peptide receptor. Cell Discov 10, 58 (2024). https://doi.org/10.1038/s41421-024-00670-3. 影响因子：38.079；并列第一.

16. Yujue Wang#, Youwei Xu#, Yue Wang, Jie Zhang, Lan Chen, Xinheng He, Wenjia Fan, Kai Wu, Wen Hu, Xi Cheng, Guizhu Yang, H.Eric Xu*, Youwen Zhuang*, and Shuyang Sun* Selective ligand recognition and activation of somatostatin receptors SSTR1 and SSTR3. PNAS 121(41) https://doi.org/10.1073/pnas.2400298121 影响因子：9.737；并列第一.

17. Jiuyin Xu#, Youwei Xu#, Li Hou#, Xinheng He#, Yang Li, Jing Zhao, Xue Meng, James Jiqi Wang, Yanli Wu, Heng Zhang, Yunhai Li, Wen Hu, Qingning Yuan, Kai Wu, Xi Cheng, Yi Jiang, Yu Xia, H Eric Xu*, and Canrong Wu* Molecular basis of lipid and ligand regulation of prostaglandin receptor DP2. PNAS 121(51) https://doi: 10.1073/pnas.2403304121影响因子：9.737；并列第一.